MIGRATING ACTION-POTENTIAL COMPLEXES - A FEATURE OF NORMAL JEJUNAL MYOELECTRIC ACTIVITY IN THE RAT
MIGRATING ACTION-POTENTIAL COMPLEXES - A FEATURE OF NORMAL JEJUNAL MYOELECTRIC ACTIVITY IN THE RAT
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DOI：
10.1139/y87-359
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发表时间：
1987-11-01
影响因子：
2.1
通讯作者：
SCOTT, RB
中科院分区：
文献类型：
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作者：
DIAMANT, SC;SCOTT, RB
为确定移行动作电位复合体(MAPC)是否为正常肠运动的一个特征，用三对间隔2.5 cm的双极空肠电极和空肠造口管记录大鼠(100~150g)的肠运动。动物在禁食18小时后，于术后第14天清醒和自由活动。在24只继续禁食的动物和12只允许喂养10分钟的动物中，记录了1小时的肠道肌电和运动活动。禁食大鼠的空肠慢波频率为32.2收缩/min，喂养后差异无统计学意义。移行性肌电复合体(MMC)在所有禁食动物中均清晰可见，其周期为10.0±-。3.6分钟。83%的MMC在II期可见MAPC，平均分布为4.2+-。3.9/MMC。摄食消除了MMC，并启动了一种连续的不规则的电脉冲模式和相关的收缩活动。摄食后可见移行动作电位复合体，频率为1.8+-。0.4/分钟。结论：MAPC是大鼠正常消化间期II期的共同特征，也是餐后空肠运动的共同特征。这支持了MAPC是正常肠道功能固有的基本推进运动模式的假设。
To determine if migrating action potential complexes (MAPCs) are a feature of normal intestinal motility, Hooded-Lister rats (100-150 g) were surgically prepared with three pairs of bipolar jejunal electrodes spaced 2.5 cm apart and with a jejunostomy tube for motility recording. Animals were studied conscious and unrestrained on postoperative day 14 after an 18-h fast. Intestinal myoelectric and motor activity was recorded for a 1-h interval in 24 animals that continued to fast and in 12 animals that were allowed to feed for 10 min. Fasting rats had a jejunal slow wave frequency of 32 .+-. 2 contractions/min which did not differ significantly after feeding. Migrating myoelectric complexes (MMC) were clearly identified in all fasting animals and had a cycle period of 10.0 .+-. 3.6 min. MAPCs were seen during phase II in 83% of MMCs and had an average distribution of 4.2 .+-. 3.9/MMC. Feeding abolished the MMC and initiated a continuous irregular pattern of electrical spiking and associated contractile activity. Migrating action potential complexes were seen after feeding with a frequency of 1.8 .+-. 0.4/min. It is concluded that MAPCs are a common feature of normal interdigestive phase II and also of postprandial jejunal motility in the rat. This supports the hypothesis that the MAPC is a basic propulsive motor pattern intrinsic to normal intestinal function.