Association and Expression Study of PRKCH Gene in a French Caucasian Population with Rheumatoid Arthritis
Association and Expression Study of PRKCH Gene in a French Caucasian Population with Rheumatoid Arthritis
复制标题
DOI：
10.1007/s10875-007-9143-6
复制
发表时间：
2008-03
影响因子：
9.1
通讯作者：
V. H. Teixeira;L. Jacq;J. Moore;S. Lasbleiz;P. Hilliquin;C. Resende Oliveira;F. Cornélis;E. Petit-Teixeira
中科院分区：
文献类型：
--
作者：
V. H. Teixeira;L. Jacq;J. Moore;S. Lasbleiz;P. Hilliquin;C. Resende Oliveira;F. Cornélis;E. Petit-Teixeira
我们研究了三种蛋白激酶C、eta基因多态性（+8134C/T、rs912620、rs9959728）与类风湿关节炎易感性之间的关系。对100个法国白种人类风湿关节炎三家系进行了基因分型。对24例非相关类风湿关节炎患者和16例健康对照者的全血中蛋白激酶C、eta mRNA的表达进行了相对定量分析。我们的研究结果显示，在蛋白激酶C、eta多态性和类风湿关节炎之间没有显著的关联或联系。蛋白激酶C， eta mRNA在类风湿关节炎无关患者中的表达水平低于健康对照组。本研究表明，蛋白激酶C， eta基因不是法国白种人类风湿关节炎的主要易感遗传因素。此外，与健康对照组相比，该基因在类风湿关节炎患者中的表达较低，这表明蛋白激酶C， eta可能与类风湿关节炎的病理生理机制有关。
We study the association between three protein kinase C, eta gene polymorphisms (+8134C/T, rs912620, rs959728), and susceptibility to rheumatoid arthritis. One hundred French Caucasian rheumatoid arthritis trio families were genotyped. Relative quantification of protein kinase C, eta mRNA expression was performed from whole blood in 24 unrelated rheumatoid arthritis patients and in 16 healthy controls. Our results showed no significant association or linkage between the protein kinase C, eta polymorphisms, and rheumatoid arthritis. The protein kinase C, eta mRNA was expressed at lower level in rheumatoid arthritis unrelated patients than in healthy controls. This study shows that protein kinase C, eta gene is not a Rheumatoid Arthritis major susceptibility genetic factor in the French Caucasian population. Furthermore, the lower expression of this gene in rheumatoid arthritis patients comparing to healthy controls suggests that protein kinase C, eta could be associated with the patho-physiologic mechanism of rheumatoid arthritis.