EFFICACY OF ORAL ANGIOTENSIN-CONVERTING ENZYME-INHIBITION WITH CAPTOPRIL THERAPY IN SEVERE CHRONIC NORMOTENSIVE CONGESTIVE HEART-FAILURE
EFFICACY OF ORAL ANGIOTENSIN-CONVERTING ENZYME-INHIBITION WITH CAPTOPRIL THERAPY IN SEVERE CHRONIC NORMOTENSIVE CONGESTIVE HEART-FAILURE
复制标题
DOI：
10.1016/0002-8703(81)90379-3
复制
发表时间：
1981-01-01
影响因子：
4.8
通讯作者：
MASON, DT
中科院分区：
文献类型：
--
作者：
AWAN, NA;EVENSON, MK;MASON, DT
为评价卡托普利口服血管紧张素转换酶抑制剂(ACE)治疗慢性血压正常的慢性充血性心力衰竭(CHF)的疗效，对10例重度CHF患者采用心导管法和前臂容积描记法测定急性心循环功能，并通过超声心动图、核心动图、平板运动试验和临床症状评定其步行功能。卡托普利(90 Mg)产生显著(峰值1h)和持续(5h)的左心室充盈压(23~15 mm Hg)，体循环阻力降低，心指数升高(1.99~2.41 L/m~2·m~2)，平均血压轻度下降(87~80 mm Hg)，心率无变化。前臂静脉张力和血管阻力明显降低。经过1wk的非卧床治疗(90 mg/d，3次/d)，核心动图射血和超声心动图短轴缩短率增加，运动时间(341~453，S)和纽约心脏协会功能分级(3.6~2.2)改善。口服卡托普利对血管紧张素转换酶诱导的血管扩张改善了顽固性充血性心力衰竭的心功能和临床状态。
To evaluate the therapeutic efficacy of oral angiotensin-converting enzyme inhibition (ACE) with captopril in chronic normotensive congestive heart failure (CHF), acute cardiocirculatory actions were determined by cardiac catheterization and forearm plethysmography, and ambulatory effects were assessed by echocardiography, nuclear angiography, treadmill exercise and clinical symptomatology in 10 severe CHF patients. Captopril (90 mg) produced marked (peak 1 h) and sustained (5 h) left ventricular filling pressure (23 to 15 mm Hg), systemic vascular resistance decreases and cardiac index increase (1.99 to 2.41 l/min per m2), while mean blood pressure declined mildly (87 to 80 mm Hg) without heart rate change. Forearm venous tone and vascular resistance decreased considerably. After 1 wk of ambulatory therapy (90 mg 3 times daily) nuclear angiographic ejection and echocardiogram shortening fractions increased, and exercise duration (341 to 453 s) and New York Heart Association functional class (3.6 to 2.2) improved. ACE-induced vasodilation by oral captopril improved cardiac performance and clinical status in refractory CHF.