Intra-articular angiofibroma of soft tissue of the knee: A case report
Intra-articular angiofibroma of soft tissue of the knee: A case report
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DOI：
10.3892/mco.2017.1298
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发表时间：
2017-08-01
影响因子：
1.2
通讯作者：
Yamamoto, Takuaki
中科院分区：
文献类型：
--
作者：
Hashino, Yuuya;Nishio, Jun;Yamamoto, Takuaki
软组织血管纤维瘤是一种非常罕见的软组织肿瘤，通常表现为生长缓慢，四肢无痛的肿块。本研究报告了一个不寻常的情况下，关节内AFST发生在左膝的23岁女性。体格检查发现一个3 cm、相对移动的、弹性硬、无压痛的肿块。磁共振成像检测到一个关节内软组织肿块，T1加权序列上相对于骨骼肌呈等信号强度，T2加权序列上呈不均匀高信号强度。对比增强的脂肪抑制T1加权序列显示了强大的周边增强的肿块。进行了关节镜下肿块切除术。组织学上，肿瘤由梭形或椭圆形细胞组成，纤维粘液样间质中有明显的血管图案。免疫组化显示肿瘤细胞弥漫性表达波形蛋白和CD 163，局灶性表达CD 68、结蛋白和雌激素受体。根据这些发现，肿瘤被诊断为AFST。在9个月的随访中，患者没有局部复发的证据。据我们所知，这是第一例关节内AFST成功的关节镜切除。
Angiofibroma of soft tissue (AFST) is an extremely rare soft tissue neoplasm that typically presents as a slow-growing, painless mass in the extremities. The present study reports an unusual case of an intra-articular AFST occurring in the left knee of a 23-year-old female. Physical examination revealed a 3-cm, relatively mobile, elastic-hard, non-tender mass. Magnetic resonance imaging detected an intra-articular soft tissue mass with iso-signal intensity relative to skeletal muscle on T1-weighted sequences and heterogeneous high signal intensity on T2-weighted sequences. Contrast-enhanced fat-suppressed T1-weighted sequences demonstrated strong peripheral enhancement of the mass. An arthroscopic excision of the mass was performed. Histologically, the tumor was composed of spindle- or oval-shaped cells in a fibromyxoid stroma with a prominent vascular pattern. Immunohistochemically, the tumor cells were diffusely positive for vimentin and CD163 and focally positive for CD68, desmin and estrogen receptor. Based on these findings, the tumor was diagnosed as an AFST. The patient had no evidence of local recurrence within 9 months of follow-up. To the best of our knowledge, this is the first case of intra-articular AFST managed successfully with arthroscopic excision.