S-ANTIGEN UVEITIS IN PRIMATES - A NEW MODEL FOR HUMAN-DISEASE
S-ANTIGEN UVEITIS IN PRIMATES - A NEW MODEL FOR HUMAN-DISEASE
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DOI：
10.1001/archopht.1981.03930011090021
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发表时间：
1981-01-01
影响因子：
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通讯作者：
WACKER, WB
中科院分区：
文献类型：
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作者：
NUSSENBLATT, RB;KUWABARA, T;WACKER, WB
用纯化的视网膜S抗原免疫恒河猴诱发葡萄膜炎。组织学上观察到局灶性视网膜和视网膜下的浸润性改变，以及周边细胞的改变。免疫的猴子和患有后葡萄膜炎的人一样，对S抗原有类似的细胞介导的体外免疫反应。未检测到发病时的循环免疫复合体。这一灵长类动物模型支持S抗原可能在人类葡萄膜炎中发挥作用的观点。
Uveitis was induced in rhesus monkeys immunized with purified retinal S-antigen. Focal retinal and subretinal infiltration, in addition to periphlebitic changes, were observed histologically. Immunized monkeys had similar cell-mediated in vitro immune responses to the S-antigen, as do humans with posterior uveitis. Circulating immune complexes at the time of disease were not detected. This primate model supports the notion that the S-antigen may play a role in human uveitis.