Stage-dependent patterns of disturbed neural synchrony in Parkinson's disease
Stage-dependent patterns of disturbed neural synchrony in Parkinson's disease
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DOI：
10.1016/s1353-8020(08)70046-4
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发表时间：
2007-01-01
影响因子：
4.1
通讯作者：
Stam, Cornelis J.
中科院分区：
文献类型：
--
作者：
Berendse, Henk W.;Stam, Cornelis J.
在分布式脑区域内和跨分布式脑区域的神经元活动的同步是皮质和皮质下网络的基本性质，并且服务于包括运动和认知过程的各种功能。本文将回顾横断面EEG和MEG研究的数据，以表明帕金森病的特征是神经同步性受干扰的模式发生变化，这些模式似乎取决于疾病的阶段。神经同步的这些改变中的一些可能直接导致运动和认知功能中的许多疾病相关损伤。未来的纵向研究需要充分了解帕金森病中功能性脑网络的干扰以及它们在整个疾病过程中如何演变。(c)2007 Elsevier B.V.保留所有权利。
Synchronization of neuronal activity within and across distributed brain regions is a fundamental property of cortical and subcortical networks and serves a variety of functions including motor and cognitive processes. Data will be reviewed here from cross-sectional EEG and MEG studies to suggest that Parkinson's disease is characterized by changing patterns of disturbed neural synchrony that appear to be dependent on the stage of disease. Some of these alterations in neural synchrony may directly account for a number of disease-related impairments in motor and cognitive functions. Future longitudinal studies are required to fully understand the disturbances of functional brain networks in Parkinson's disease and how they evolve throughout the course of the disease. (c) 2007 Elsevier B.V. All rights reserved.