Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials.
Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials.
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DOI：
10.1186/s12929-016-0289-5
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发表时间：
2016-11-04
影响因子：
11
通讯作者：
Yen BL
中科院分区：
文献类型：
--
作者：
Wang LT;Ting CH;Yen ML;Liu KJ;Sytwu HK;Wu KK;Yen BL
人间充质干细胞（MSC）是多谱系体细胞祖细胞/干细胞，近年来已被证明具有免疫调节特性。 MSC 免疫调节最初受到很多质疑，但现在已在组织来源和物种中得到很好的复制，具有临床相关性。这开辟了这些多功能细胞在细胞替代/组织再生以及免疫和炎症介导的疾病实体中作为第三方/同种异体用途的用途。最令人惊讶的是，使用间充质干细胞治疗免疫/炎症介导的疾病似乎比再生医学更有效，因为似乎不需要外源细胞的植入。在这篇综述中，我们重点关注组织特异性干细胞的非传统临床应用，并重点介绍干细胞治疗这一令人兴奋的领域的重要发现和趋势。
Human mesenchymal stem cells (MSCs) are multilineage somatic progenitor/stem cells that have been shown to possess immunomodulatory properties in recent years. Initially met with much skepticism, MSC immunomodulation has now been well reproduced across tissue sources and species to be clinically relevant. This has opened up the use of these versatile cells for application as 3rd party/allogeneic use in cell replacement/tissue regeneration, as well as for immune- and inflammation-mediated disease entities. Most surprisingly, use of MSCs for in immune-/inflammation-mediated diseases appears to yield more efficacy than for regenerative medicine, since engraftment of the exogenous cell does not appear necessary. In this review, we focus on this non-traditional clinical use of a tissue-specific stem cell, and highlight important findings and trends in this exciting area of stem cell therapy.
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影响因子：
2.6
作者：
Bartholomew, A;Sturgeon, C;Hoffman, R
通讯作者：
Hoffman, R
影响因子：
5.2
作者：
Chang, Chun-Jung;Yen, Men-Luh;Yen, B. Linju
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Yen, B. Linju
影响因子：
4.4
作者：
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通讯作者：
Navarrete, Cristina V.
DOI：
10.1152/ajplung.00182.2009
发表时间：
2010-12-01
影响因子：
4.9
作者：
Bonfield, Tracey L.;Koloze, Mary;Caplan, Arnold I.
通讯作者：
Caplan, Arnold I.
影响因子：
5.2
作者：
Auletta, Jeffery J.;Eid, Saada K.;Wuttisarnwattana, Patiwet;Silva, Ines;Metheny, Leland;Keller, Matthew D.;Guardia-Wolff, Rocio;Liu, Chen;Wang, Fangjing;Bowen, Theodore;Lee, Zhenghong;Solchaga, Luis A.;Ganguly, Sudipto;Tyler, Megan;Wilson, David L.;Cooke, Kenneth R.
通讯作者：
Cooke, Kenneth R.