Frequency of the G/G genotype of resistin single nucleotide polmorphism at -420 appears to be increased in younger-onset type 2 diabetes
Frequency of the G/G genotype of resistin single nucleotide polmorphism at -420 appears to be increased in younger-onset type 2 diabetes
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DOI：
10.2337/db06-1157
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发表时间：
2007-11-01
期刊：
影响因子：
7.7
通讯作者：
Makino, Hideichi
中科院分区：
文献类型：
--
作者：
Ochi, Masaak;Osawa, Haruhiko;Makino, Hideichi
抗胰岛素抵抗素是一种脂肪细胞分泌的细胞因子，与小鼠的胰岛素抵抗有关。我们以前报道过，在-420位点的G-G单核苷酸多态性（SNP）的G/G基因型通过增强其启动子活性而增加2型糖尿病易感性。本研究的目的是确定SNP - 120的相关性在大量的subjects.Research设计和方法-我们检查了2,610 2型糖尿病病例和2,502对照组。通过增加237例发病年龄为40岁的2型糖尿病受试者，进一步分析SNP-420与2型糖尿病发病年龄的关系。结论-当不考虑受试者年龄进行分析时，SNP-420基因型与2型糖尿病无关。由于我们报道了2型糖尿病的发病在G/G基因型中较早，因此我们使用10岁年龄间隔的趋势检验来分析数据。2型糖尿病患者G/G基因型频率在不同年龄组间存在差异（P = 0.037），且年轻组的G/G基因型频率较高。在2型糖尿病患者中，G/G基因型在≥ 40岁的受试者中更常见（G/G vs. C/C，P = 0.003）。在总共2，430例2型糖尿病受试者中，
OBJECTIVE-Resistin is an adipocyte-secreted cytokine associated with insulin resistance in mice. We previously reported that the G/G genotype of a resistin single nucleotide polymorphism (SNP) at -420 increases type 2 diabetes susceptibility by enhancing its promoter activity. The aim of the present study was to determine the relevance of SNP - 120 in a large number of subjects.RESEARCH DESIGN AND METHODS- We examined 2,610 type 2 diabetic case and 2,502 control subjects. The relation between SNP -420 and the age of type 2 diabetes onset was further analyzed by adding 237 type 2 diabetic subjects with age of onset: 40 years.RESULTS-When analyzed without considering subject age, the SNP -420 genotype was not associated with type 2 diabetes. Since we reported that the onset of type 2 diabetes was earlier in G/G genotype, we analyzed the data using a trend test for age intervals of 10 years. The frequency of G/G genotype differed among age grades in type 2 diabetes (P = 0.037) and appeared to be higher in younger grades. In type 2 diabetes, G/G genotype was more frequent in subjects aged = 40 years (G/G vs. C/C, P = 0.003). In a total of 2,430 type 2 diabetic subjects with age of onset