Transport of RNA between nucleus and cytoplasm.
Transport of RNA between nucleus and cytoplasm.
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DOI：
10.1016/1043-4682(92)90029-u
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发表时间：
1992-08-01
期刊：
影响因子：
--
通讯作者：
Mattaj, I W
中科院分区：
文献类型：
--
作者：
Izaurralde, E;Mattaj, I W
RNA聚合酶II(U、SnRNAs和mRNAs)转录的RNA的核外转运尚未得到广泛研究。基本的问题，例如出口是否需要将RNA与特定的蛋白质联系起来，还没有明确的答案。尽管如此，最近在这一领域取得了重大进展。已经确定了出口所需或导致核滞留的RNA的序列或结构特征。据推测，它们分别与运输机械的部件或锚定的核因素相互作用。某些mRNAs的运输依赖于插入序列或来自特定启动子的转录，这一未知的依赖性表明，RNAs在输出之前可能必须通过不同的核内室。对从细胞质输入的RNA的研究表明，存在不同类别的核定位信号，并且已经确定了病毒RNPs的蛋白质组分，这些蛋白质组分似乎决定了它们穿过核膜的方向。
The transport out of the nucleus of RNAs transcribed by RNA polymerase II (U snRNAs and mRNAs) has not been extensively studied. Basic questions, such as whether export requires association of the RNA with specific proteins, are not yet definitively answered. Nevertheless, recent progress in this area has been significant. Sequence or structural features of RNAs which are either required for export or which result in nuclear retention have been defined. These are presumed to interact with components of the transport machinery or with anchoring nuclear factors respectively. The unexplained dependence of the transport of certain mRNAs on either intervening sequences or for transcription from specific promoters suggests that RNAs may have to pass through different intranuclear compartments before export. Studies of the import of RNAs from the cytoplasm has revealed that different classes of nuclear localization signals exist, and protein components of viral RNPs that appear to determine the direction in which they move through the nuclear envelope have been identified.