Comparison of naloxonazine and beta-funaltrexamine antagonism of mu 1 and mu 2 opioid actions.
Comparison of naloxonazine and beta-funaltrexamine antagonism of mu 1 and mu 2 opioid actions.
复制标题
纳洛嗪和β-富纳曲明对 mu 1 和 mu 2 阿片类药物作用的拮抗作用的比较。
DOI：
10.1016/0024-3205(91)90155-5
复制
发表时间：
1991
期刊：
影响因子：
6.1
通讯作者：
Pasternak,GW
中科院分区：
文献类型：
--
作者：
Pick,CG;Paul,D;Pasternak,GW
Compared the actions of naloxonazine and β-funaltrexamine (β-FNA) against opioid analgesia, gastrointestinal transit, and lethality in male mice. Naloxonazine effectively antagonized the analgesia produced by morphine without significantly affecting morphine's actions on either gastrointestinal transit or lethality. In contrast, β-FNA effectively antagonized all 3 morphine actions. Both naloxonazine and β-FNA administered 24 hrs earlier potently antagonized supraspinal DAMGO analgesia. Naloxonazine blocked supraspinal analgesia over 6-fold more potently than spinal analgesia. In contrast, β-FNA antagonized intrathecal DAMGO as effectively as icv DAMGO and at the spinal level was 5-fold more potent than naloxonazine. β-FNA remains a valuable tool in the classification of μ opioid actions. To subclassify μ actions, naloxonazine can be used.(PsycINFO Database Record (c) 2016 APA, all rights reserved)
