Bioactive lipids as modulators of immunity, inflammation and emotions
Bioactive lipids as modulators of immunity, inflammation and emotions
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DOI：
10.1016/j.coph.2016.06.005
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发表时间：
2016-08-01
影响因子：
4
通讯作者：
Maccarrone, Mauro
中科院分区：
文献类型：
--
作者：
Chiurchiu, Valerio;Maccarrone, Mauro
脂类不仅是细胞膜的组成部分，也是关键的信号媒介，因此起着生物活性脂类的作用。生物活性脂质发挥的突出作用是免疫调节、炎症和维持体内平衡。越来越多的证据表明，免疫和神经系统之间存在双向关系，炎症介质可以直接调节情绪，而情绪反过来又可以强烈影响免疫反应，从而影响健康。本文综述了几类生物活性脂质调节免疫和炎症的能力(通过促炎或抗炎作用)，以及控制情绪和情绪相关表现的能力，提倡这些物质是‘心’和‘体’之间有吸引力的界面，并作为治疗炎症性/免疫介导性情绪障碍的潜在靶点。
Lipids are not only constituents of cellular membranes but also key signaling mediators, thus acting as 'bioactive lipids'. Among the prominent roles exerted by bioactive lipids are immune regulation, inflammation and maintenance of homeostasis. Accumulated evidence indicates the existence of a bidirectional relationship between immune and nervous systems, whereby inflammatory mediators can directly modulate emotions that, in turn, can strongly influence immune responses, thus affecting health. This review summarizes current knowledge on the ability of several families of bioactive lipids to regulate immunity and inflammation (through pro inflammatory or anti-inflammatory effects), as well as to control emotions and mood-related manifestations, advocating these substances as an attractive interface between 'mind' and 'body', and as a potential target to treat inflammatory/immunemediated mood disorders.