Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease.
Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease.
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DOI：
10.1371/journal.pone.0078554
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Pike CJ
中科院分区：
文献类型：
--
作者：
Barron AM;Rosario ER;Elteriefi R;Pike CJ
阿尔茨海默病(AD)的发病机制涉及多种代谢综合征因素，包括腹型肥胖、胰岛素抵抗、内分泌功能紊乱和血脂异常。高脂饮食是肥胖和代谢综合征的常见实验模型，已被证明在动物模型中会加速认知能力下降和AD相关的神经病理。然而，性行为与高脂肪饮食的代谢结果相互作用，因此，可能会改变饮食操作的神经病理后果。这项研究考察了性别和高脂饮食对3xTg-AD小鼠代谢和AD相关神经病理结果的影响。3月龄雄性和雌性3xTg-AD小鼠分别饲喂标准和高脂饲料4个月。所有高脂喂养的小鼠都观察到肥胖；然而，只有雄性小鼠才能观察到异位脂肪堆积、高血糖和高胰岛素血症。有趣的是，尽管高脂饮食的代谢结果不同，但神经病理后果是相似的：在高脂饮食下维持的雄性和雌性小鼠的行为表现和海马区β-淀粉样蛋白的积累都显著恶化。由于高脂饮食导致男女肥胖和AD样病理增加，这些数据支持肥胖相关因素在促进AD发病中的作用。
Multiple factors of metabolic syndrome have been implicated in the pathogenesis of Alzheimer's disease (AD), including abdominal obesity, insulin resistance, endocrine dysfunction and dyslipidemia. High fat diet, a common experimental model of obesity and metabolic syndrome, has been shown to accelerate cognitive decline and AD-related neuropathology in animal models. However, sex interacts with the metabolic outcomes of high fat diet and, therefore, may alter neuropathological consequences of dietary manipulations. This study examines the effects of sex and high fat diet on metabolic and AD-related neuropathological outcomes in 3xTg-AD mice. Three month-old male and female 3xTg-AD mice were fed either standard or high fat diets for 4 months. Obesity was observed in all high fat fed mice; however, ectopic fat accumulation, hyperglycemia and hyperinsulinemia were observed only in males. Interestingly, despite the different metabolic outcomes of high fat diet, the neuropathological consequences were similar: both male and female mice maintained under high fat diet exhibited significant worsening in behavioral performance and hippocampal accumulation of β-amyloid protein. Because high fat diet resulted in obesity and increased AD-like pathology in both sexes, these data support a role of obesity-related factors in promoting AD pathogenesis.
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影响因子：
5.8
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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