Morphologic characteristics of Chernobyl-related childhood papillary thyroid carcinomas are independent of radiation exposure but vary with iodine intake
Morphologic characteristics of Chernobyl-related childhood papillary thyroid carcinomas are independent of radiation exposure but vary with iodine intake
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DOI：
10.1089/thy.2008.0039
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发表时间：
2008-08-01
期刊：
影响因子：
6.6
通讯作者：
Thomas, Geraldine A.
中科院分区：
文献类型：
--
作者：
Williams, E. Dillwyn;Abrosimov, Alexander;Thomas, Geraldine A.
背景资料：切尔诺贝利事故导致了甲状腺乳头状癌（PTC）发病率的空前增加，其潜伏期短得惊人，形态异常。我们调查了切尔诺贝利事故后PTC发病率的意外特征是否是辐射特异性的或受碘deficiency.Methods影响：PTCs从白俄罗斯，乌克兰和俄罗斯联邦的儿童暴露于切尔诺贝利的沉降物进行了比较PTCs从儿童不暴露于辐射来自同一国家，从英格兰和威尔士（E&W）和日本。分化的程度和类型，纤维化，和invasion进行了quantitation.Results：有PTCs从辐射暴露的儿童从白俄罗斯，乌克兰和俄罗斯联邦和PTCs从同一国家的儿童谁没有暴露于辐射之间没有显着差异。日本的儿童PTCs比“Eubyl”肿瘤分化更高（p <0.001），表现出更多的乳头状分化（p <0.001），侵袭性更低（p < 0.01），而来自E&W的肿瘤通常表现出中等水平的分化和侵袭程度和类型。有辐射暴露的PTCs儿童与未暴露的PTCs儿童的性别比有显著差异（F：M暴露与未暴露1.5：1与4.2：1; χ 2 = 7.90，p
Background: The Chernobyl accident caused an unprecedented increase in papillary thyroid carcinoma (PTC) incidence with a surprisingly short latency and unusual morphology. We have investigated whether unexpected features of the PTC incidence after Chernobyl were radiation specific or influenced by iodine deficiency.Methods: PTCs from children from Belarus, Ukraine, and the Russian Federation exposed to fallout from Chernobyl were compared with PTCs from children not exposed to radiation from the same countries, from England and Wales (E&W) and from Japan. The degree and type of differentiation, fibrosis, and invasion were quantified.Results: There were no significant differences between PTCs from radiation-exposed children from Belarus, Ukraine, and the Russian Federation and PTCs from children from the same countries who were not exposed to radiation. Childhood PTCs from Japan were much more highly differentiated (p < 0.001), showed more papillary differentiation (p < 0.001) and were less invasive (p < 0.01) than "Chernobyl'' tumors, while tumors from E&W generally showed intermediate levels of degree and type of differentiation and invasion. There was a marked difference between the sex ratios of children with PTCs who were radiation exposed and those who were not exposed (F: M exposed vs. unexposed 1.5:1 vs. 4.2:1; chi(2) 7.90, p