Treatment of long bone non-unions with polytherapy: Indications and clinical results
Treatment of long bone non-unions with polytherapy: Indications and clinical results
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DOI：
10.1016/j.injury.2011.03.046
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发表时间：
2011-06-01
影响因子：
2.5
通讯作者：
Tagliabue, L.
中科院分区：
文献类型：
--
作者：
Calori, G. M.;Mazza, E.;Tagliabue, L.
据估计，长骨不连的发生率在5%到10%之间。自体骨移植通常取自髂骨，仍然是生物增强萎缩性骨不连的金标准。然而，其使用一直受到供体部位或大或小并发症的阻碍。此外，尽管具有成骨性、骨导电性和一些骨诱导性的特性，但治疗的总体结果并不一致，有时成功率令人失望。多疗法治疗骨不连的概念，即同时应用金刚石概念的三个基本要素，骨祖细胞、生长因子和骨传导支架，似乎是一个有吸引力的选择，但需要更多的研究来验证这一策略。(C) 2011 Elsevier Ltd.版权所有。
The incidence of long bone non-unions has been estimated to range between 5 and 10%. Autologous bone graft usually harvested from the iliac crest continues to be the gold standard for biological enhancement of atrophic non-unions. However, its use has been hampered by minor and major donor site complications. Moreover despite possessing the properties of osteogenecity, osteoconductivity and some osteoinductivity the overall results of treatment have not been consistent with disappointing success rates at times. The concept of polytherapy for the treatment of non-unions, namely the simultaneous application of the three fundamental elements of the diamond concept, osteoprogenitor cells, growth factor and osteoconductive scaffold, appears to be an attractive alternative but more studies are desirable to validate this strategy. (C) 2011 Elsevier Ltd. All rights reserved.