Myocardial function in offspring 5-8 years after pregnancy complicated by preeclampsia
Myocardial function in offspring 5-8 years after pregnancy complicated by preeclampsia
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DOI：
10.1016/j.earlhumdev.2011.04.006
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发表时间：
2011-08-01
影响因子：
2.5
通讯作者：
Staff, Anne Cathrine
中科院分区：
文献类型：
--
作者：
Fugelseth, Drude;Ramstad, Heidi Bente;Staff, Anne Cathrine
简介：先兆子痫和糖尿病妊娠具有共同的病理生理学特征，这些特征表明影响胎儿生命期间的表观遗传变化，对以后的发育、代谢和心血管疾病具有重要意义。目的：我们的目的是研究妊娠并发症后后代的心肌。方法：45个孩子（年龄5-8岁）从妊娠并发先兆子痫分娩（n = 25），包括1型糖尿病（n = 8）或妊娠期糖尿病（n = 12）。15名正常妊娠的儿童作为对照。结果：妊娠并发症组与对照组比较，左、右心室心肌功能无明显差异。然而，与对照组和糖尿病组相比，先兆子痫组的心脏更小，心率增加，二尖瓣附件舒张晚期速度（A '波）增加（脉冲波和彩色TDI）（p
Introduction: Preeclampsia and diabetic pregnancies share pathophysiological features suggested to influence epigenetic changes during foetal life with importance for later development and metabolic and cardiovascular diseases.Aim: Our objective was to study the myocardium in offspring after pregnancy complications.Methods: Forty-five children (age 5-8 years) delivered from pregnancies complicated by preeclampsia (n = 25), diabetes mellitus type 1 (n = 8) or gestational diabetes mellitus (n = 12) were included. Fifteen children from uneventful pregnancies served as controls. Myocardial functions of right and left ventricle were examined by conventional Doppler and tissue Doppler imaging (TDI).Results: No major differences were found in the myocardial function between offspring of pregnancy complications and control group. However, the preeclampsia group had smaller hearts, increased heart rate and increased late diastolic velocity (A'-wave) at mitral valve attachments shown by both pulsed wave and colour TDI compared to the control and diabetic groups together (p