Genetic association studies in nursing practice and scholarship.
Genetic association studies in nursing practice and scholarship.
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护理实践和学术中的遗传关联研究。
DOI：
10.1111/j.1547-5069.2008.00228.x
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Read,CatherineY
中科院分区：
文献类型：
--
作者：
Underwood,PatriciaC;Read,CatherineY
目的：探讨遗传关联研究在常见复杂疾病风险评估中的作用。组织框架：介绍遗传关联研究的类型，并讨论它们在老年性黄斑变性和2型糖尿病风险评估中的潜在应用。这项新兴技术的好处和局限性被探索并与护理实践和学术相关。结论：实习护士必须准备好帮助客户决定寻找和解释遗传关联研究的结果，护士研究人员必须使用当前的指南来进行强有力的研究并将此类研究的结果应用于临床实践。临床相关性：从遗传关联研究收集的数据将越来越多地被用于确定许多复杂疾病的新预防和治疗策略。对于临床实践中所有领域的护士来说，理解作为这门新科学基础的原则是至关重要的，因为他们基于遗传关联研究设计、测试和实施适当的干预和预防策略。
Purpose:To explore the role of genetic association studies in risk assessment for common complex diseases.Organizing Framework:An introduction to the types of genetic association studies is followed by a discussion of their potential use in risk assessment for age‐related macular degeneration and type 2 diabetes mellitus. The benefits and limitations of this burgeoning technology are explored and related to nursing practice and scholarship.Conclusions:Nurses in practice must be prepared to assist clients with decisions about seeking and interpreting results from genetic association studies and nurse researchers must apply current guidelines for conducting robust studies and applying the results of such studies in clinical practice.Clinical Relevance:Data collected from genetic association studies will increasingly be used to identify novel prevention and treatment strategies for many complex diseases. An understanding of the principles that underlie this new science is essential for nurses in all areas of clinical practice as they design, test, and implement appropriate intervention and prevention strategies based on genetic association studies.