A new avenue to cure cancer by turning adaptive immune T cells to innate immune NK cells via reprogramming.
A new avenue to cure cancer by turning adaptive immune T cells to innate immune NK cells via reprogramming.
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DOI：
10.1093/jmcb/mjq016
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发表时间：
2010-10
影响因子：
5.5
通讯作者：
D. Su;R. Vankayalapati
中科院分区：
文献类型：
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作者：
D. Su;R. Vankayalapati
T细胞系定型后的胸腺细胞在T细胞途径中发育。然而，在最近的研究中，Li等人（2010）证明，诱导缺失这些胸腺细胞中的Bcl11b基因，甚至在成熟T细胞中，在培养期间将这些细胞转变为自然杀伤（NK）细胞。他们称这种转换为“重编程”，重编程的杀伤细胞为“ITNK细胞”。ITNK细胞具有肿瘤杀伤能力，并且不滥杀正常细胞。这一令人兴奋的发现代表了治疗癌症的重大突破，并确定了胸腺发育中一种重要的新型转录因子。
Thymocytes after T-lineage commitment develop in the T-cell pathway. However, in a recent study, Li et al. (2010) demonstrated that inducing to delete Bcl11b gene in these thymocytes, even in mature T cells turns these cells into natural killer (NK) cells during the culture. They called this conversion 'reprogramming', and the reprogrammed killer cells 'ITNK cells'. The ITNK cells possessed tumor-killer ability and did not indiscriminately kill normal cells. This exciting finding represents a major breakthrough towards curing cancer and identifies an important, novel transcription factor in the thymus development.