A population-based study of peripheral arterial disease prevalence with special focus on critical limb ischemia and sex differences
A population-based study of peripheral arterial disease prevalence with special focus on critical limb ischemia and sex differences
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DOI：
10.1016/j.jvs.2007.02.004
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发表时间：
2007-06-01
影响因子：
4.3
通讯作者：
Wahlberg, Eric
中科院分区：
文献类型：
--
作者：
Sigvant, Birgitta;Wiberg-Hedman, Katarina;Wahlberg, Eric
目的：一个以人口为基础的点患病率的研究，以确定在瑞典的外周动脉疾病（PAD）的患病率，特别注意严重的肢体缺血和性别differences.Methods：一个年龄标准化的随机选择的人口样本8000名妇女和男子，年龄在60至90岁，从四个不同的地区在瑞典被邀请参加。样本的年龄和性别分布与瑞典人口在这一年龄组相同。参与者完成了关于病史、目前用药和症状的问卷调查，并测量了他们的踝臂指数（ABI）。结果：共纳入5080例受试者，参与率为64%。任何PAD、无症状PAD、间歇性跛行和严重肢体缺血的患病率分别为18%（95%置信区间[CI]，16%-20%）、11%（9%-13%）、7%（6.5 - 7%）和1.2%（1%-1.5%）。当PAD仅诊断为ABI时，女性的患病率高于男性;即无症状PAD（12.6% vs 9.4%，P = 0.03）和严重肢体缺血（1.5% vs 0.8%，P <0.008）。任何PAD的患病率在60至65岁年龄组中为7.9%，在85至90岁年龄组中增加至47.2%。严重肢体缺血在最年轻年龄组中发生率为0.3%，在80至84岁年龄组中最高，为3.3%，在最年长的年龄组中下降至2.5%。PAD的患病率在不同地区之间存在差异（P < .0001）。结论：PAD在瑞典很常见，几乎五分之一的老年人患有这种疾病。妇女比男子更经常受到折磨。严重缺血的患病率，作为衡量严重肢体缺血的指标，约占人口的1%。
Objective: A population-based point-prevalence study was conducted to determine the prevalence of peripheral arterial disease (PAD) in Sweden, with special attention to critical limb ischemia and sex differences.Methods: An age-standardized randomly selected population sample of 8000 women and men, aged 60 to 90 years, from four different regions in Sweden was invited to participate. The sample had the same age and gender distribution as the Swedish population in this age group. Participating subjects completed questionnaires on medical history, present medication, and symptoms, and their ankle-brachial index (ABI) was measured. Subjects were analyzed for presence of PAD according to reported symptoms and an ABI < 0.9.Results: A total of 5080 subjects were included, giving a participation rate of 64%. The prevalence of any PAD, asymptomatic PAD, intermittent claudication, and severe limb ischemia was, respectively, 18% (95% confidence interval [CI], 16% to 20%) 11% (9% to 13%), 7% (6.5 to 7%) and 1.2% (1% to 1.5%). Women had a higher prevalence than men when PAD was diagnosed with ABI only; that is, asymptomatic PAD (12.6% vs 9.4%, P =.03) and severe limb ischemia (1.5% vs 0.8%, P < .008). The prevalence of any PAD was 7.9% in the age group 60 to 65 years and increased to 47.2% among the age group 85 to 90 years. Severe limb ischemia occurred in 0.3% in the youngest age group, was highest in the age group 80 to 84 years at 3.3%, and declined to 2.5% among the oldest. The prevalence of PAD differed between regions (P < .0001).Conclusions: PAD is common in Sweden, and almost a fifth of all elderly individuals have some stage of this disease. Women are more often afflicted than men. The prevalence of severe ischemia, as a measure of critical limb ischemia, is about 1% the population.