NEUROPATHOLOGY OF IMMUNOHISTOCHEMICALLY IDENTIFIED BRAIN-STEM NEURONS IN PARKINSONS-DISEASE
NEUROPATHOLOGY OF IMMUNOHISTOCHEMICALLY IDENTIFIED BRAIN-STEM NEURONS IN PARKINSONS-DISEASE
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DOI：
10.1002/ana.410270405
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发表时间：
1990-04-01
影响因子：
11.2
通讯作者：
GEFFEN, LB
中科院分区：
文献类型：
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作者：
HALLIDAY, GM;LI, YW;GEFFEN, LB
将4例特发性帕金森病患者脑干连续切片中化学鉴定神经元的区域丢失与4例年龄匹配的对照受试者的等效切片进行比较。在帕金森病脑中，中脑、脑桥和髓质的儿茶酚胺细胞群表现出不同的神经病理学变化。所有多巴胺能神经核均受到影响，但在尾侧中央黑质中受到的影响最严重。脑桥去甲肾上腺素能蓝斑表现出不同程度的变性。在脚桥被盖核中也有大量含P物质的神经元丢失。然而，在脑桥中受影响最严重的细胞群是中缝中缝中的降钙素合成神经元。在延髓，大量的神经元损失被发现在几个不同的细胞群，包括肾上腺素合成和神经肽Y的神经元在延髓头端腹外侧，在中缝暗核的合成神经元，在外侧网状结构的P物质的神经元，以及在迷走神经背侧运动核的P物质的神经元。路易体存在于许多这些区域的化学鉴定的神经元中，表明它们直接受到疾病过程的影响。这些广泛但区域和发射器特异性的变化有助于解释帕金森病运动、认知和自主神经表现的多样性。
Regional loss of immunohistochemically identified neurons in serial sections through the brainstem of 4 patients with idiopathic Parkinson''s disease was compared with equivalent sections from 4 age-matched control subjects. In the Parkinson brains, the catecholamine cell groups of the midbrain, pons, and medulla showed variable neuropathological changes. All dopaminergic nuclei were variably affected, but were most severely affected in the caudal, central substantia nigra. The pontine noradrenergic locus ceruleus showed variable degrees of degeneration. There was also a substantial loss of substance P-containing neurons in the pedunculopontine tegmental nucleus. However, the most severely affected cell group in the pons was the serotonin-synthesizing neurons in the median raphe. In the medulla, substantial neuronal loss was found in several diverse cell groups including the adrenaline-synthesizing and neuropeptide Y-containing neurons in the rostral ventrolateral medulla, the serotonin-synthesizing neurons in the raphe obscurus nucleus, the substance P-containing neurons in the lateral reticular formation, as well as the substance P-containing neurons in the dorsal motor vagal nucleus. Lewy bodies were present in immunohistochemically identified neurons in many of these regions, indicating that they were affected directly by the disease process. These widespread but region- and transmitter-specific changes help account for the diversity of motor, cognitive, and autonomic manifestations of Parkinson''s disease.