Hysterectomy, menopause, and estrogen use preceding Parkinson's disease: An exploratory case-control study
Hysterectomy, menopause, and estrogen use preceding Parkinson's disease: An exploratory case-control study
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DOI：
10.1002/mds.1170
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发表时间：
2001-09-01
影响因子：
8.6
通讯作者：
Rocca, WA
中科院分区：
文献类型：
--
作者：
Benedetti, MD;Maraganore, DM;Rocca, WA
我们研究了帕金森病（PD）与绝经类型（自然或手术）的关系。更年期的年龄。绝经后雌激素替代疗法采用病例对照设计。我们使用罗彻斯特流行病学项目的医疗记录链接系统来识别1976-1995年间明尼苏达州奥姆斯特德县72名患帕金森病的妇女。每个病例按年龄（+/- 1岁）与一般人群对照受试者相匹配。我们通过审查系统中病例和对照对象的完整医疗记录收集暴露数据。PD患者行子宫切除术（合并或不合并单侧卵巢切除术）的频率明显高于对照组（优势比[or] = 3.36； 95%可信区间[CI] = 1.05-10.77）。此外，PD患者比对照组更常经历早期绝经（小于或等于46年）（or = 2.18, 95% CI = 0.88-5.39）。最后，PD患者在绝经后至少6个月口服或静脉注射雌激素的频率（8%）低于对照组（14%;or = 0.47, 95% CI = 0.12-1.85）。然而，早期绝经和雌激素替代疗法的研究结果没有统计学意义。尽管这项探索性研究的样本量有限，但我们假设在导致内源性雌激素早期减少的情况下，PD的风险增加。这一假设需要在更大的研究中得到证实。(C) 2001运动障碍学会。
We studied the association of Parkinson's disease (PD) with type of menopause (natural or surgical). age at menopause. and postmenopausal estrogen replacement therapy using a case-control design. We used the medical records-linkage system of the Rochester Epidemiology Project to identify 72 women who developed PD in Olmsted County, MN, during the twenty years 1976-1995. Each incident case was matched by age (+/- 1 year) to a general population control subject. We collected exposure data through review of the complete medical records of cases and control subjects in the system. PD cases had undergone hysterectomy (with or without unilateral oophorectomy) significantly more often than control subjects (odds ratio [OR] = 3.36; 95% confidence interval [CI] = 1.05-10.77). In addition, PD cases had experienced early menopause (less than or equal to 46 years) more commonly than control subjects (OR = 2.18, 95% CI = 0.88-5.39). Finally, PD cases had used estrogens orally or parenterally for at least 6 months after menopause less frequently (8%) than control subjects (14%; OR = 0.47, 95% CI = 0.12-1.85). However, the findings for early menopause and estrogen replacement therapy were not statistically significant. Despite the limited sample size of this exploratory study, we hypothesize that there is an increased risk of PD in conditions causing an early reduction in endogenous estrogen. This hypothesis needs to be confirmed in a larger study. (C) 2001 Movement Disorder Society.