Analysis of ECOG performance status in head and neck squamous cell carcinoma patients: association with sociodemographical and clinical factors, and overall survival
Analysis of ECOG performance status in head and neck squamous cell carcinoma patients: association with sociodemographical and clinical factors, and overall survival
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DOI：
10.1007/s00520-012-1386-y
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发表时间：
2012-11-01
影响因子：
3.1
通讯作者：
Batista De Paula, Alfredo Mauricio
中科院分区：
文献类型：
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作者：
Batista Correa, Gefter Thiago;Bandeira, Gabriela Alencar;Batista De Paula, Alfredo Mauricio
在本研究中，我们分析了头颈鳞状细胞癌（HNSCC）患者的社会人口统计学和临床因素以及东部肿瘤合作组体能状态（ECOG-PS）量表。我们评估了一系列变量对总体生存率的影响。我们利用社会人口学和临床信息以及从流行病学、临床和治疗报告回顾中收集的生存数据，调查了 HNSCC 患者样本 (n = 671)。通过双变量和多变量统计检验分析统计关联。统计显着性设定为 p < 0.05。85.4% 的患者记录了良好的 ECOG-PS 评分。较差的 ECOG-PS 评分与吞咽困难 [比值比 (OR) = 2.660，CI 95% = 1.661-4.260，p = 0.000] 和大尺寸恶性疾病 (T3-T4；OR = 5.337，CI 95% = 2.251-12.652，p = 0.000) 的协变量相关。总体生存分析显示，ECOG-PS 评分（OR = 1.879，CI 95% = 1.162-3.038，p = 0.010）、肿瘤大小（OR = 1.665，CI 95% = 1.035-2.680，p = 0.036）以及是否存在宫颈转移（OR = 3.145，CI 95% = 2.008-4.926，p = 0.000）是独立的预测因子。头颈癌患者诊断时的体力消耗评估可能表明恶性疾病更具侵袭性。因此，ECOG-PS 量表可能有助于识别需要快速转诊的 HNSCC 患者，这些患者可能会受益于特定的治疗和康复干预措施。
In the present study, we analyzed sociodemographical and clinical factors, and the Eastern Cooperative Oncology Group performance status (ECOG-PS) scale in head and neck squamous cell carcinoma (HNSCC) patients. We evaluated the impact of a range of variables on overall survival.We investigated a sample of HNSCC patients (n = 671), using sociodemographical and clinical information, and survival data collected from a review of epidemiological, clinical, and treatment reports. Statistical associations were analyzed by bivariate and multivariate statistical tests. Statistical significance was set at p < 0.05.Of patients 85.4% recorded good ECOG-PS scores. Poor ECOG-PS scores were associated with the covariates indicative of dysphagia [odd ratios (OR) = 2.660, CI 95% = 1.661-4.260, p = 0.000] and large-size malignant disease (T3-T4; OR = 5.337, CI 95% = 2.251-12.652, p = 0.000). Overall survival analysis revealed that ECOG-PS scores (OR = 1.879, CI 95% = 1.162-3.038, p = 0.010), tumor size (OR = 1.665, CI 95% = 1.035-2.680, p = 0.036), and the presence of cervical metastasis (OR = 3.145, CI 95% = 2.008-4.926, p = 0.000) were independent predictors.Evaluation of physical consumption in head and neck cancer patients at diagnosis may indicate a more aggressive type of malignant disease. Thus, the ECOG-PS scale may help to identify HNSCC patients in need of rapid referral, who may benefit from specific therapeutic and rehabilitative interventions.