Enantiomer resolution of nefopam hydrochloride, a novel analgesic: a study by liquid chromatography and circular dichroism spectroscopy
Enantiomer resolution of nefopam hydrochloride, a novel analgesic: a study by liquid chromatography and circular dichroism spectroscopy
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新型镇痛药盐酸奈福泮对映体拆分：液相色谱和圆二色光谱研究
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
I. Agranat
中科院分区：
文献类型：
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作者：
R. Isaksson;J. Sandström;Michal Eliaz;Zehorith Israely;I. Agranat
Abstract— Nefopam, a potent analgesic, has been completely resolved into enantiomers on a preparative scale by low‐pressure liquid chromatography on swollen, microcrystalline triacetylcellulose. The enantiomerically pure hydrochlorides were prepared from the base, and the circular dichroism spectra of the free base and the hydrochloride are reported.
