Tea consumption and the risk of depression: A meta-analysis of observational studies
Tea consumption and the risk of depression: A meta-analysis of observational studies
复制标题
DOI：
10.1177/0004867414567759
复制
发表时间：
2015-04-01
影响因子：
4.6
通讯作者：
Lu, Zuxun
中科院分区：
文献类型：
--
作者：
Dong, Xiaoxin;Yang, Chen;Lu, Zuxun
目的：喝茶是否能降低抑郁症的风险仍然存在争议。我们进行了一项荟萃分析的观察性研究的结果，以评估茶叶消费和抑郁风险之间的关联。方法：Embase，PubMed和中国国家知识基础设施数据库检索从成立到2014年8月的观察性研究，报告了茶叶消费和抑郁风险之间的关联。当异质性可忽略时，我们使用固定效应模型，当异质性显著时，我们使用随机效应模型来计算汇总相对风险估计值（RR）和95%置信区间（CI）。结果：11项研究（13篇报告）符合纳入荟萃分析的条件（22，817例受试者，4，743例抑郁症）。与茶叶消费量较低的个体相比，茶叶消费量较高的个体的抑郁风险合并RR为0.69（95%CI：0.63-0.75）。8份报告被纳入了茶叶消费和抑郁风险的剂量反应分析（10，600名参与者，2，107例病例）。饮茶量与抑郁风险呈线性相关，饮茶量每增加3杯/天，抑郁风险降低37%（RR = 0.63，95%CI：0.55-0.71）。
Objective: Whether tea consumption decreases the risk of depression remains controversial. We performed a meta-analysis of findings from observational studies to evaluate the association between tea consumption and depression risk.Method: Embase, PubMed, and Chinese National Knowledge Infrastructure databases were searched from their inception through August 2014 for observational studies that had reported the association between tea consumption and depression risk. We used a fixed effects model when heterogeneity was negligible and a random effect model when heterogeneity was significant to calculate the summary relative risk estimates (RRs) and 95% confidence intervals (CIs).Results: Eleven studies with 13 reports were eligible for inclusion in the meta-analysis (22,817 participants with 4,743 cases of depression). Compared to individuals with lower tea consumption, those with higher tea consumption had a pooled RR of depression risk at 0.69 (95% CI: 0.63-0.75). Eight reports were included in the dose-response analysis of tea consumption and depression risk (10,600 participants with 2,107 cases). There was a linear association between tea consumption and the risk of depression, with an increment of 3 cups/day in tea consumption associated with a decrease in the risk of depression of 37% (RR = 0.63, 95% CI: 0.55-0.71).Conclusion: Tea consumption is associated with a decreased risk of depression.