Consumption of Sericin Reduces Serum Lipids, Ameliorates Glucose Tolerance and Elevates Serum Adiponectin in Rats Fed a High-Fat Diet
Consumption of Sericin Reduces Serum Lipids, Ameliorates Glucose Tolerance and Elevates Serum Adiponectin in Rats Fed a High-Fat Diet
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DOI：
10.1271/bbb.100065
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发表时间：
2010-08-01
影响因子：
1.6
通讯作者：
Kato, Norihisa
中科院分区：
文献类型：
--
作者：
Okazaki, Yukako;Kakehi, Shoko;Kato, Norihisa
研究了饲粮中的丝胶蛋白对高脂饲料喂养的大鼠的脂质和碳水化合物代谢的影响。用含20%牛脂的饲料喂饲大鼠5周，其中含或不含4%的丝胶蛋白。最终体重和白色脂肪组织重量不受饮食控制的影响。丝胶蛋白的消耗显着降低血清甘油三酯，胆固醇，磷脂和游离脂肪酸的水平。血清极低密度脂蛋白（VLDL）-甘油三酯，极低密度脂蛋白胆固醇，低密度脂蛋白（LDL）-胆固醇和LDL-磷脂也显着降低了丝胶摄入量。肝脏甘油三酯和葡萄糖6-磷酸脱氢酶和苹果酸酶的活性，脂肪生成酶，也降低了由丝胶摄入量。饲粮中添加丝胶引起血清脂联素显著升高。在腹腔注射葡萄糖后，丝胶蛋白的消耗抑制了血糖和胰岛素水平的升高。这些结果表明，丝胶蛋白可改善高脂饮食大鼠的脂质和碳水化合物代谢。
The effect was examined of dietary sericin on the lipid and carbohydrate metabolism in rats fed with a high-fat diet. The rats were fed with a 20% beef tallow diet with or without sericin at the level of 4% for 5 weeks. The final body weight and white adipose tissue weight were unaffected by dietary manipulation. The consumption of sericin significantly reduced the serum levels of triglyceride, cholesterol, phospholipids and free fatty acids. Serum very-low-density lipoprotein (VLDL)-triglyceride, VLDL-cholesterol, low-density lipoprotein (LDL)-cholesterol and LDL-phospholipids were also significantly reduced by the sericin intake. Liver triglyceride and the activities of glucose 6-phosphate dehydrogenase and malic enzyme, the lipogenic enzymes, were also reduced by the sericin intake. Dietary sericin caused a marked elevation in serum adiponectin. The consumption of sericin suppressed the increases in plasma glucose and insulin levels after an intraperitoneal glucose injection. These results imply the usefulness of sericin for improving the lipid and carbohydrate metabolism in rats fed on a high-fat diet.