Aminobromination of β-Nitrostyrene Derivatives with N,N-Dibromourethane as the Aminobrominating Reagent
Aminobromination of β-Nitrostyrene Derivatives with N,N-Dibromourethane as the Aminobrominating Reagent
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DOI：
10.1002/ejoc.201100751
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发表时间：
2011-10-01
影响因子：
2.8
通讯作者：
Wang, Yun
中科院分区：
文献类型：
--
作者：
Chen, Zhan-Guo;Zhao, Peng-Fei;Wang, Yun
A concise and efficient aminobromination reaction for beta-nitrostyrene derivatives by treatment with N,N-dibromourethane was developed. For the beta-nitrostyrene derivatives, the aminobromination successfully proceeded at room temperature in CH3CN without catalysis or protection by an inert gas and gave products in excellent yields (80-97%). For the beta-methyl analogs, the reaction proceeded smoothly with anhydrous K2CO3 as a catalyst under the same conditions to provide the aminobrominated products in good yields (53-78%). A possible pathway for this electrophilic addition reaction is proposed.
