ENDOTHELIN IN CORONARY ENDOTHELIAL DYSFUNCTION AND EARLY ATHEROSCLEROSIS IN HUMANS
ENDOTHELIN IN CORONARY ENDOTHELIAL DYSFUNCTION AND EARLY ATHEROSCLEROSIS IN HUMANS
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DOI：
10.1161/01.cir.92.9.2426
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发表时间：
1995-11-01
期刊：
影响因子：
37.8
通讯作者：
BURNETT, JC
中科院分区：
文献类型：
--
作者：
LERMAN, A;HOLMES, DR;BURNETT, JC
Background The endothelium modulates vascular lone through release of vasodilating substances, such as endothelium-derived relaxing factors, and vasoconstricting substances, such as endothelin. Endothelin concentrations are elevated in humans with atherosclerosis and in hypercholesterolemic pigs. Furthermore, the endothelium-dependent vasodilator acetylcholine increases endothelin in hypercholesterolemia in association with coronary vasoconstriction. The present study was designed to test the hypotheses that coronary endothelial dysfunction in humans is characterized by enhanced coronary and circulating endothelin and that the vasoconstriction associated with acetylcholine results in further release of coronary endothelin.Methods and Results Coronary and circulating endothelin concentrations were measured at baseline and during intracoronary acetylcholine administration in 20 patients undergoing diagnostic coronary angiography. Patients were divided into two groups on the basis of their response to intracoronary acetylcholine. Group 1 (n=7) demonstrated a normal vasodilatory response, but group 2 (n=13) demonstrated coronary vasoconstriction. Baseline coronary and circulating endothelin concentrations (as determined by coronary sinus and femoral artery measurements, respectively) were higher in patients who responded to acetylcholine with coronary vasoconstriction (group 2) than in group 1 patients (coronary sinus, 15.9+/-1.0 pg/mL versus 7.1+/-1.0 pg/mL; femoral, 14.1+/-0.9 pg/mL versus 6.8+/-1.0 pg/mL, respectively; P
