Serum levels of erythropoietin as a novel marker reflecting the severity of diabetic nephropathy
Serum levels of erythropoietin as a novel marker reflecting the severity of diabetic nephropathy
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作者：
Inomata, S;Itoh, M;Sato, T
据报道，促红细胞生成素（EPO）主要由肾小管周围间质细胞产生，血清促红细胞生成素水平可能为糖尿病肾病患者小管间质病变提供新的信息。我们检测了63例糖尿病患者的EPO、血红蛋白（Hb）和Hb x EPO，这些患者表现为正常、微量或大量蛋白尿，肾功能正常或降低（肌酐清除率，Ccr，大于或等于60ml /min或< 60ml /min）。此外，我们对13例显性肾病、肾功能正常的患者进行了平均26个月的Ccr随访，结果如下：(1)Hb、EPO、Hb × EPO值随着肾病的进展而逐渐降低，(2)6例肾功能快速下降的患者初始EPO、Hb × EPO值明显低于7例无肾功能下降的患者（p < 0.01）。我们认为EPO和Hb x EPO值可能是预测糖尿病显性肾病患者未来慢性肾功能衰竭的新指标。
Erythropoietin (EPO) is reported to be mainly produced by renal peritubular interstitial cells, Serum levels of EPO may provide new information on the tubulointerstitial lesions in patients with diabetic nephropathy. We determined EPO, hemoglobin (Hb), and Hb x EPO in 63 diabetic patients who showed norma-, micro- or macroalbuminuria with normal or reduced renal function (creatinine clearance, Ccr, greater than or equal to 60 ml/min or < 60 ml/min). In addition, we followed up Ccr during a mean of 26 months in 13 patients with overt nephropathy and normal renal function, The following results were obtained: (1) Hb, EPO, and Hb x EPO values gradually decreased along with advancing stages of nephropathy, and (2) 6 patients with rapidly decreasing renal function sowed significantly lower initial EPO and Hb x EPO values than 7 patients without it (p < 0.01). We conclude that EPO and Hb x EPO values may be a new marker predicting future chronic renal failure in diabetic overt nephropathy.