Role of 4-1BB:4-1BB ligand in cancer immunotherapy
Role of 4-1BB:4-1BB ligand in cancer immunotherapy
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DOI：
10.1038/sj.cgt.7700670
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发表时间：
2004-03-01
影响因子：
6.4
通讯作者：
Guinn, BA
中科院分区：
文献类型：
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作者：
Cheuk, ATC;Mufti, GJ;Guinn, BA
T细胞的活化在抗肿瘤免疫中起着核心作用。为了激活初始T细胞，需要两个关键信号。信号一是通过T细胞受体（TCR）提供的，而信号二是共刺激。CD 28：B7分子是研究得最好的共刺激途径之一，被认为是主要的T细胞刺激机制。然而，已经鉴定了许多分子，其在初始T细胞活化后用于放大和多样化T细胞应答。这些包括最近描述的4-1BB：4-1BB配体（4-1BBL）分子。4-1BB：4-1BBL是TNFR：TNF配体家族的成员，其分别在T细胞和抗原呈递细胞（APC）上表达。利用4-1BB：4-1BBL信号传导途径的疗法已显示在许多模型系统中具有抗肿瘤作用。本文主要研究4-1BB：4-1BBL共刺激分子。特别是，我们将描述4-1BB分子的结构和功能，其受体以及4-1BB：4-1BBL共刺激如何用于癌症的免疫治疗。
The activation of T cells plays a central role in antitumor immunity. In order to activate naive T cells, two key signals are required. Signal one is provided through the T-cell receptor (TCR) while signal two is that of costimulation. The CD28:B7 molecules are one of the best-studied costimulatory pathways, thought to be the main mechanism through which primary T-cell stimulation occurs. However, a number of molecules have been identified which serve to amplify and diversify the T-cell response, following initial T-cell activation. These include the more recently described 4-1BB:4-1BB ligand (4-1BBL) molecules. 4-1BB:4-1BBL are a member of the TNFR: TNF ligand family, which are expressed on T cells and antigen-presenting cells (APCs), respectively. Therapies utilizing the 4-1BB:4-1BBL signaling pathway have been shown to have antitumor effects in a number of model systems. In this paper, we focus on the 4-1BB: 4-1BBL costimulatory molecules. In particular, we will describe the structure and function of the 4-1BB molecule, its receptor and how 4-1BB:4-1BBL costimulation has and may be used for the immunotherapy of cancer.