Bax inserts into the mitochondrial outer membrane by different mechanisms
Bax inserts into the mitochondrial outer membrane by different mechanisms
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DOI：
10.1016/j.febslet.2008.07.047
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发表时间：
2008-09-03
期刊：
影响因子：
3.5
通讯作者：
Vallette, Francois M.
中科院分区：
文献类型：
--
作者：
Cartron, Pierre-Francois;Bellot, Gregory;Vallette, Francois M.
Bax插入线粒体外膜是实现细胞凋亡的必要条件。然而，对Bax整合到线粒体外膜的第一阶段知之甚少。我们最近表明，线粒体外膜受体TOM22对插入很重要，尽管其他报道表明只有线粒体脂质参与这一过程。在这里，我们发现Bax的单体，而不是二聚体，需要TOM22和TOM40的存在才能整合到线粒体中。此外，我们发现一旦插入细胞膜，Bax可以作为细胞质Bax的受体。(C) 2008年欧洲生化学会联合会。Elsevier b.v.版权所有。
Bax insertion into the mitochondrial outer membrane is essential for the implementation of apoptosis. However, little is known about the first stage of Bax integration into the mitochondrial outer membrane. We have recently shown that TOM22, a mitochondrial outer membrane receptor, is important for insertion, although other reports have suggested that only mitochondrial lipids are involved in this process. Here, we show that monomers, but not dimers, of Bax require the presence of TOM22 and TOM40 to integrate into mitochondria. In addition we show that once inserted into the membrane, Bax can act as a receptor for cytosolic Bax. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.