Automatic control of simulated moving beds
Automatic control of simulated moving beds
复制标题
模拟移动床自动控制
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
Jay H. Lee
中科院分区：
文献类型：
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作者：
Gültekin Erdem;Stefanie Abel;M. Morari;M. Mazzotti;M. Morbidelli;Jay H. Lee
模拟移动床（SMB）色谱已成为制药和精细化工行业广泛使用的分离技术。然而，由于缺乏适当的过程控制方案，中小企业在经济最佳状态下的运营仍然是一个悬而未决的问题。这项工作提出了一种基于在线优化的控制概念，以避免过程的稳健性和生产率之间的权衡，并加速 SMB 分离的发展。该控制概念需要最少的系统信息，即亨利常数和柱的平均孔隙率。本文阐述了仅基于线性吸附等温线参数的控制器如何为应用于具有非线性竞争等温线特征的系统的 SMB 找到正确的操作条件，以便首先满足产品规格，然后优化操作的经济性。针对解决 SMB 操作中主要挑战的多种场景对控制器的性能进行了评估。
Simulated moving bed (SMB) chromatography has become a widely used separation technology in the pharmaceutical and fine chemical industries. However, operation of SMBs at their economic optimum is still an open issue because of the absence of proper process control schemes. This work proposes an on-line optimization-based control concept to avoid the tradeoff between the robustness and productivity of the process and to accelerate the development of SMB separations. The control concept requires minimal information on the system, i.e., Henry's constants and the average porosity of the columns. This paper illustrates how a controller that is based only on the linear adsorption isotherm parameters can find the correct operating conditions for the SMB applied to a system characterized by a nonlinear competitive isotherm in order first to fulfill the product specifications and then to optimize the economics of the operation. The performance of the controller is assessed for several scenarios addressing the main challenges in SMB operation.