Engrams and circuits crucial for systems consolidation of a memory
Engrams and circuits crucial for systems consolidation of a memory
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DOI：
10.1126/science.aam6808
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发表时间：
2017-04-07
期刊：
影响因子：
56.9
通讯作者：
Tonegawa, Susumu
中科院分区：
文献类型：
--
作者：
Kitamura, Takashi;Ogawa, Sachie K.;Tonegawa, Susumu
情节记忆最初需要在海马体内快速的突触可塑性来形成，并逐渐巩固在新皮质网络中以进行永久存储。然而，到目前为止，支持新皮质记忆巩固的印记和电路尚不清楚。我们发现，新皮质前额叶记忆印记细胞是远程情景恐惧记忆的关键，在最初的学习过程中，通过来自海马-内嗅觉皮质网络和基底外侧杏仁核的输入，迅速产生了新皮质前额叶记忆印记细胞。前额叶印记细胞生成后，在海马记忆印记细胞的支持下，随着时间的推移，功能逐渐成熟。虽然随着时间的推移，海马区的印记细胞逐渐变得沉默，但杏仁核基底外侧的印记细胞保持不变，这是恐惧记忆所必需的。我们的数据为记忆整合系统基础上的印记和电路的功能重组提供了新的见解。
Episodic memories initially require rapid synaptic plasticity within the hippocampus for their formation and are gradually consolidated in neocortical networks for permanent storage. However, the engrams and circuits that support neocortical memory consolidation have thus far been unknown. We found that neocortical prefrontal memory engram cells, which are critical for remote contextual fear memory, were rapidly generated during initial learning through inputs from both the hippocampal-entorhinal cortex network and the basolateral amygdala. After their generation, the prefrontal engram cells, with support from hippocampal memory engram cells, became functionally mature with time. Whereas hippocampal engram cells gradually became silent with time, engram cells in the basolateral amygdala, which were necessary for fear memory, were maintained. Our data provide new insights into the functional reorganization of engrams and circuits underlying systems consolidation of memory.