Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics
Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics
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DOI：
10.1093/gerona/61.6.562
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发表时间：
2006-06-01
影响因子：
5.1
通讯作者：
Bartke, A
中科院分区：
文献类型：
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作者：
Bonkowski, MS;Pamenter, RW;Bartke, A
关于生长激素(GH)在控制衰老中的生理作用，目前存在相互矛盾的信息。本研究报告了用双能X射线吸收法(DXA)测量年轻、成年和老年长寿生长激素受体基因敲除(GHR-KO)小鼠和正常小鼠的身体成分和骨骼特征，以确定GH抵抗在衰老过程中的影响。与对照组相比，GHR-KO小鼠的体脂百分比增加。GHR-KO小鼠全身骨密度(BMD)、骨矿含量和骨面积降低，但这些参数随着年龄的增长而增加。此外，与所有年龄组的对照组相比，GHR-KO小鼠的股骨长度、股骨骨密度和腰椎骨密度都有所降低。这些参数也随着年龄的增长而继续增加。我们的结果表明，生长激素抵抗改变了GHR-KO小鼠衰老过程中的身体成分、骨生长和骨维护。
There is conflicting information on the physiological role of growth hormone (GH) in the control of aging. This study reports dual-energy x-ray absorptiometry (DXA) measurements of body composition and bone characteristics in young, adult, and aged long-lived GH receptor knockout (GHR-KO) and normal mice to determine the effects of GH resistance during aging. Compared to controls, GHR-KO mice showed an increased percentage of body fat. GHR-KO mice have reduced total-body bone mineral density (BMD), bone mineral content, and bone area, but these parameters increased with age. In addition, GHR-KO mice have decreased femur length, femur BMD, and lower lumbar BMD compared to controls in all age groups. These parameters also continued to increase with age. Our results indicate that GH resistance alters body composition, bone growth, and bone maintenance during aging in GHR-KO mice.