Assessment of glomerular filtration rate during pregnancy using the MDRD formula
Assessment of glomerular filtration rate during pregnancy using the MDRD formula
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DOI：
10.1111/j.1471-0528.2007.01529.x
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发表时间：
2008-01-01
影响因子：
5.8
通讯作者：
Davison, J. M.
中科院分区：
文献类型：
--
作者：
Smith, M. C.;Moran, P.;Davison, J. M.
现在推荐使用估计的肾小球滤过率（eGFR）值来筛查和监测慢性肾脏疾病。在一般人群中最常用的公式是根据肾脏疾病饮食调整（MDRD）研究描述的公式，其中血清肌酐根据年龄，性别和种族进行调整。本研究通过比较正常妊娠早期和晚期以及合并肾脏疾病或子痫前期妊娠的菊粉清除研究获得的eGFR与测量值来评估MDRD配方在妊娠中的性能。我们的研究结果表明，在所有情况下，MDRD都大大低估了妊娠期间的肾小球滤过率，因此不能推荐用于临床实践。
It is now recommended practice to use estimated glomerular filtration rate (eGFR) values to screen for and monitor chronic renal disease. The most frequently used formula in the general population is that described following the Modification of Diet in Renal Disease (MDRD) study whereby serum creatinine is adjusted for age, gender and race. This study evaluates the performance of the MDRD formula in pregnancy by comparing eGFR with measured values obtained by inulin clearance studies in early and late normal pregnancy and in pregnancies complicated by renal disease or pre-eclampsia. Our results indicate that in all situations, MDRD substantially underestimates glomerular filtration rate during pregnancy and cannot be recommended for use in clinical practice.