Exploring Host-Pathogen Interactions through Biological Control
Exploring Host-Pathogen Interactions through Biological Control
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DOI：
10.1371/journal.ppat.1004865
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发表时间：
2015-06-01
期刊：
影响因子：
6.7
通讯作者：
Holmes, Edward C.
中科院分区：
文献类型：
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作者：
Di Giallonardo, Francesca;Holmes, Edward C.
入侵性害虫给农业和自然环境带来了重大负担，威胁着一些本地物种的灭绝。虽然化学剂经常被用来消灭害虫，但非特异性毒性使它们的使用不受欢迎。生物制剂作为一种替代方法，以淘汰特定的害虫物种，几乎没有残留的环境危害的兴趣。故意释放微生物病原体，称为生物防治，迄今为止，主要涉及病毒。在这里，我们总结了过去和建议的脊椎动物害虫生物防治的应用。尽管存在可以理解的恐惧，但脊椎动物生物防治尚未与不利影响联系起来，并提供了大规模的自然实验，以了解宿主与病原体之间的密切相互作用。
Invasive pests impose a major burden on the agricultural industries and the natural environment, threatening some native species with extinction. Although chemical agents are often deployed to eliminate pests, unspecific toxicity makes their use undesirable. Biological agents are of interest as an alternative method to cull specific pest species with little residual environmental harm. The deliberate release of microbial pathogens, referred to as biological control (biocontrol), has, to date, largely involved viruses. Here, we summarise the past and proposed applications of the biocontrol of vertebrate pests. Despite understandable fears, vertebrate biocontrol has yet to be associated with adverse effects, and provides large-scale natural experiments by which to understand the intimate interactions between hosts and their pathogens.