Heritability of physical activity traits in Brazilian families: the Baependi Heart Study.
Heritability of physical activity traits in Brazilian families: the Baependi Heart Study.
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DOI：
10.1186/1471-2350-12-155
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发表时间：
2011-11-29
影响因子：
--
通讯作者：
Pereira AC
中科院分区：
文献类型：
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作者：
Horimoto AR;Giolo SR;Oliveira CM;Alvim RO;Soler JP;de Andrade M;Krieger JE;Pereira AC
人们普遍认为，体力活动具有家族聚集性，然而，遗传对体力活动表型的影响还没有得到很好的表征。本研究旨在（1）估计巴西家庭的体力活动性状的遗传力;（2）调查遗传和环境方差分量是否对男性和女性这些表型的表达有不同的贡献。Baependi心脏研究的样本由95个巴西家庭的1，693人组成。表型在基于WHO-MONICA工具的问卷中自我报告。方差分量法，在SOLAR（顺序寡基因连锁分析软件包）的计算机程序包中实现，被用来估计遗传力和评估方差分量的异质性，由性别对所研究的表型。非久坐受试者每周体力活动（每周PA_NS）的遗传力估计值为中等（35%），久坐、每周体力活动（每周PA）和每日体力活动水平（每日PA）的遗传力估计值较低（9-14%）。显著证据的异质性方差组分的性别观察久坐症和每周PA表型。没有显着的性别差异，遗传或环境方差分量观察每周PA_NS性状。每日PA表型主要受环境因素的影响，男性比女性的影响更大。在巴西人口的这一样本中的体力活动表型的遗传力估计是显着的男性和女性，从低到中等幅度不等。观察到按性别的方差分量异质性的显著证据。这些数据增加了巴西研究人群的身体活动特征的知识，并与积极行为的重要生物决定的概念是一致的。
It is commonly recognized that physical activity has familial aggregation; however, the genetic influences on physical activity phenotypes are not well characterized. This study aimed to (1) estimate the heritability of physical activity traits in Brazilian families; and (2) investigate whether genetic and environmental variance components contribute differently to the expression of these phenotypes in males and females. The sample that constitutes the Baependi Heart Study is comprised of 1,693 individuals in 95 Brazilian families. The phenotypes were self-reported in a questionnaire based on the WHO-MONICA instrument. Variance component approaches, implemented in the SOLAR (Sequential Oligogenic Linkage Analysis Routines) computer package, were applied to estimate the heritability and to evaluate the heterogeneity of variance components by gender on the studied phenotypes. The heritability estimates were intermediate (35%) for weekly physical activity among non-sedentary subjects (weekly PA_NS), and low (9-14%) for sedentarism, weekly physical activity (weekly PA), and level of daily physical activity (daily PA). Significant evidence for heterogeneity in variance components by gender was observed for the sedentarism and weekly PA phenotypes. No significant gender differences in genetic or environmental variance components were observed for the weekly PA_NS trait. The daily PA phenotype was predominantly influenced by environmental factors, with larger effects in males than in females. Heritability estimates for physical activity phenotypes in this sample of the Brazilian population were significant in both males and females, and varied from low to intermediate magnitude. Significant evidence for heterogeneity in variance components by gender was observed. These data add to the knowledge of the physical activity traits in the Brazilian study population, and are concordant with the notion of significant biological determination in active behavior.