High testosterone levels in prostate tissue obtained by needle biopsy correlate with poor-prognosis factors in prostate cancer patients.
High testosterone levels in prostate tissue obtained by needle biopsy correlate with poor-prognosis factors in prostate cancer patients.
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DOI：
10.1186/1471-2407-14-717
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发表时间：
2014-09-26
期刊：
影响因子：
3.8
通讯作者：
Kubota Y
中科院分区：
文献类型：
--
作者：
Miyoshi Y;Uemura H;Umemoto S;Sakamaki K;Morita S;Suzuki K;Shibata Y;Masumori N;Ichikawa T;Mizokami A;Sugimura Y;Nonomura N;Sakai H;Honma S;Harada M;Kubota Y
前列腺组织和血液中雄激素浓度与前列腺癌分期和病理分级之间的相关性目前尚无共识。在这项研究中，我们使用了一种新开发的超灵敏液相色谱串联质谱法测量睾酮（T）和双氢睾酮（DHT）的浓度在血液和前列腺穿刺活检标本前列腺癌患者。我们分析了196名诊断为前列腺癌的男性的雄激素水平。所有患者均接受了系统性穿刺活检，并从外周区进行了额外的穿刺活检，以同时测定T和DHT。我们使用多变量分析，分析了组织和血液中T和DHT水平与Gleason评分、临床分期和阳性活检针百分比之间的关系。血液中T和DHT水平的中位数分别为3551.0 pg/mL和330.5 pg/mL。血清T与双氢睾酮有较强的相关性。前列腺组织中T和DHT的中位数分别为0.5667 pg/mg和7.0625 pg/mg。在多变量分析中，血清前列腺特异性抗原和组织T水平与不良预后显著相关;前列腺组织中的高T水平与高Gleason评分（p = 0.041）、晚期临床分期（p = 0.002）和高阳性活检芯百分比（p = 0.001）显著相关。这项研究的结果表明，前列腺组织中的高T水平与前列腺癌患者的高Gleason评分、晚期临床分期和高百分比的阳性活检芯相关。因此，针吸活检标本中的T水平可能是前列腺癌患者的一个有用的预后因素。本文的在线版本（doi：10.1186/1471-2407-14-717）包含补充材料，可供授权用户使用。
There is currently no consensus on the correlations between androgen concentrations in prostate tissue and blood and stage and pathological grade of prostate cancer. In this study, we used a newly-developed ultra-sensitive liquid-chromatography tandem mass spectrometry method to measure testosterone (T) and dihydrotestosterone (DHT) concentrations in blood and needle biopsy prostate specimens from patients with prostate cancer. We analyzed androgen levels in 196 men diagnosed with prostate cancer. All patients had undergone systematic needle biopsy, and an additional needle biopsy from the peripheral zone was conducted for the simultaneous determination of T and DHT. We analyzed the relationships between T and DHT levels in tissue and blood and Gleason score, clinical stage, and percentage of positive biopsy cores, using multivariate analysis. The median T and DHT levels in blood were 3551.0 pg/mL and 330.5 pg/mL, respectively. There was a strong correlation between serum T and DHT. The median T and DHT levels in prostate tissue were 0.5667 pg/mg and 7.0625 pg/mg, respectively. In multivariate analysis, serum prostate-specific antigen and tissue T levels were significantly associated with poor prognosis; high T levels in prostate tissue were significantly related to high Gleason score (p = 0.041), advanced clinical stage (p = 0.002), and a high percentage of positive biopsy cores (p = 0.001). The results of this study indicate that high T levels in prostate tissue are related to high Gleason score, advanced clinical stage, and a high percentage of positive biopsy cores in patients with prostate cancer. T level in needle biopsy specimens may therefore be a useful prognostic factor in prostate cancer patients. The online version of this article (doi:10.1186/1471-2407-14-717) contains supplementary material, which is available to authorized users.
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影响因子：
7.3
作者：
DEWINTER, JAR;TRAPMAN, J;VANDERKWAST, TH
通讯作者：
VANDERKWAST, TH
影响因子：
11.5
作者：
Titus, MA;Schell, MJ;Mohler, JL
通讯作者：
Mohler, JL
DOI：
10.1046/j.1464-410x.1996.89120.x
发表时间：
1996-03-01
期刊：
BRITISH JOURNAL OF UROLOGY
影响因子：
--
作者：
Gustafsson, O;Norming, U;Nyman, CR
通讯作者：
Nyman, CR
影响因子：
6.6
作者：
Thomas, Lynn N.;Douglas, Robert C.;Too, Catherine K. L.
通讯作者：
Too, Catherine K. L.
影响因子：
2.8
作者：
VERMEULEN, A;GIAGULLI, VA;STONER, E
通讯作者：
STONER, E