Co-expression of VEGF-C and its receptors, VEGFR-2 and VEGFR-3, in endothelial cells of lymphangioma. Implication in autocrine or paracrine regulation of lymphangioma
Co-expression of VEGF-C and its receptors, VEGFR-2 and VEGFR-3, in endothelial cells of lymphangioma. Implication in autocrine or paracrine regulation of lymphangioma
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DOI：
10.1038/labinvest.3780386
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发表时间：
2001-12-01
影响因子：
5
通讯作者：
Hsu, SM
中科院分区：
文献类型：
--
作者：
Huang, HY;Ho, CC;Hsu, SM
淋巴管瘤一直被认为是先天性畸形所造成的失败，淋巴管沟通静脉系统在胎儿期。或者，它被认为是起源于淋巴内皮细胞转化的真正肿瘤。为探讨淋巴管瘤发病机制的分子基础，我们应用RNA原位杂交技术，对29例淋巴管瘤组织中血管内皮生长因子（VEGF）及其受体（VEGFR）的表达进行了研究。淋巴管瘤的内皮细胞共表达VEGF-C及其受体VEGFR-3（Flt 4）和VEGFR-2（Flk 1）的转录本，这些转录本在邻近结缔组织中检测不到。相反，血管瘤、血管瘤或小肠或大肠的正常淋巴管的内皮细胞中很少或没有VEGF-C、VEGFR-3和VEGFR-2 mRNA的表达。提示VEGF-C及其受体可能通过自分泌或旁分泌调节在淋巴管瘤的形成中起积极作用。
Lymphangioma has long been thought of as congenital malformations resulting from the failure of lymphatic vessels communicating with the venous system in the fetal period. Alternatively, it is proposed to be true neoplasm originated from the transformation of lymphatic endothelia. To extend the molecular basis of the pathogenesis of lymphangioma, we have characterized the expression of vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFR) in 29 cases of lymphangioma by RNA in situ hybridization. Endothelial cells of lymphangioma co-express transcripts of VEGF-C and its receptors VEGFR-3 (Flt4) and VEGFR-2 (Flk1), which are not detectable in the adjacent connective tissue. In contrast, there is little or no expression of VEGF-C, VEGFR-3, and VEGFR-2 mRNA in endothelial cells of hemangiomas, angiosarcomas, or normal lymphatic vessels of the small or large intestines. The results suggest that VEGF-C and its receptors may take active parts in the formation of lymphangioma by autocrine or paracrine regulation.