A LARGE FAMILY OF BACTERIAL ACTIVATOR PROTEINS
A LARGE FAMILY OF BACTERIAL ACTIVATOR PROTEINS
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DOI：
10.1073/pnas.85.18.6602
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发表时间：
1988-09-01
影响因子：
11.1
通讯作者：
WALLACE, JC
中科院分区：
文献类型：
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作者：
HENIKOFF, S;HAUGHN, GW;WALLACE, JC
至少有九种不同的细菌蛋白属于LysR家族。这里给出了其中一种蛋白质的基因序列。另外六个(大肠杆菌LysR、Ilvy、CysB、鼠伤寒沙门氏菌、根瘤杆菌和阴沟肠杆菌Ampr)已知可以激活其他基因。根据序列比对，这个家族的每个成员都在其氨基末端附近。综合证据表明，所有九种蛋白质都有共同的祖先，相似的折叠，并且与其他已知的细菌调节蛋白没有明显的相关性。本研究中使用的DNA数据库搜索程序和其他方法将有助于检测其他相关蛋白质组。
At least nine different bacterial proteins belong to the LysR family. The gene sequence for one of these proteins is presented here. Six others (Escherichia coli LysR, IlvY, CysB, Salmonella typhimurium MetR; Rhizobium NodD; and Enterobacter cloacae AmpR) are known to activate other genes. Based on sequence alignments, each member of this family near its amino terminus. The combined evidence indicates that all nine proteins are related by common ancestry, are similarly folded, and are not detectably related to other known bacterial regulatory proteins. The DNA database searching procedure and other methods used in this study should be useful in detecting other groups of related proteins.