Transcriptional enhancers: Intelligent enhanceosomes or flexible billboards?
Transcriptional enhancers: Intelligent enhanceosomes or flexible billboards?
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DOI：
10.1002/jcb.20352
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发表时间：
2005-04-01
影响因子：
4
通讯作者：
Kulkarni, MM
中科院分区：
文献类型：
--
作者：
Arnosti, DN;Kulkarni, MM
在高等真核生物中，转录增强子在细胞信号传导信息的整合中发挥着关键作用，但除了一些经过充分研究的模型增强子之外，我们缺乏对大多数增强子的转录信息处理的总体了解。在这里，我们讨论了最近的研究，这些研究为增强子上发生的信息处理提供了新的见解，并提出，除了“增强体”的高度合作和协调作用之外，信息显示或“广告牌”增强子还介导了一种不太综合但更灵活的信息处理形式。这些模型的应用不仅对转录的生化分析产生重要影响，而且对更广泛的生物信息学和进化生物学领域也产生重要影响。 (c) 2005 年 Wiley-Liss, Inc.
in higher eukaryotes, transcriptional enhancers play critical roles in the integration of cellular signaling information, but apart from a few well-studied model enhancers, we lack a general picture of transcriptional information processing by most enhancers. Here we discuss recent studies that have provided fresh insights on information processing that occurs on enhancers, and propose that in addition to the highly cooperative and coordinate action of "enhanceosomes", a less integrative, but more flexible form of information processing is mediated by information display or "billboard" enhancers. Application of these models has important ramifications not only for the biochemical analysis of transcription, but also for the wider fields of bioinformatics and evolutionary biology. (c) 2005 Wiley-Liss, Inc.