Protein import into mitochondria
Protein import into mitochondria
复制标题
DOI：
10.1042/bst0331019
复制
发表时间：
2005-11-01
影响因子：
3.9
通讯作者：
Neupert, W
中科院分区：
文献类型：
--
作者：
Mokranjac, D;Neupert, W
线粒体由大约。1000到3000种不同的蛋白质，几乎所有的蛋白质都必须从细胞质中输入到细胞器中。到目前为止，已经确定了六种复杂的分子机器，蛋白质转位，介导这一过程。TIM23复合体是线粒体内膜的主要转位酶。它利用两种能量来源，即膜电位和ATIP，促进蛋白前体跨内膜易位并插入内膜。最近的研究发现了TIM23复合物的一些新成分，并揭示了前蛋白易位的机制。
Mitochondria comprise approx. 1000-3000 different proteins, almost all of which must be imported from the cytosol into the organelle. So far, six complex molecular machines, protein translocases, were identified that mediate this process. The TIM23 complex is a major translocase in the inner mitochondrial membrane. It uses two energy sources, namely membrane potential and ATIP, to facilitate preprotein translocation across the inner membrane and insertion into the inner membrane. Recent research has led to the discovery of a number of new constituents of the TIM23 complex and to the unravelling of the mechanisms of preprotein translocation.