THE EFFECT OF REGULAR EXERCISE ON WOMEN RECEIVING DANAZOL FOR TREATMENT OF ENDOMETRIOSIS
THE EFFECT OF REGULAR EXERCISE ON WOMEN RECEIVING DANAZOL FOR TREATMENT OF ENDOMETRIOSIS
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DOI：
10.1016/0020-7292(95)02359-k
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发表时间：
1995-06-01
影响因子：
3.8
通讯作者：
KIMBALL, A
中科院分区：
文献类型：
--
作者：
CARPENTER, SE;TJADEN, B;KIMBALL, A
目的：探讨常规运动对接受达那唑治疗子宫内膜异位症的疗效。方法：在三级医疗机构进行的前瞻性临床试验中，39例患者随机分为单用达那唑组和达那唑加运动组，每组每周锻炼4次，每次40min，强度为20个代谢单位。比较所有受试者的副作用、盆腔症状、有氧能力、力量和激素水平。用广义估计方程的方法对丹那唑的副作用进行分析。结果：在4周的时间里，单用丹那唑的副作用是丹那唑/运动组的1.09-2.17倍。所有患者在治疗过程中症状均有改善，达那唑/运动组治疗期间睾酮水平明显降低，子宫内膜异位症复发时间两组间无差异。结论。达那唑治疗期间的锻炼可以减少雄激素副作用的数量。疼痛缓解和复发时间不受影响。
Objective: To determine the effects of regular exercise on women receiving danazol for the treatment of endometriosis, Methods: Thirty-nine patients were randomized to a danazol-only or a danazol/exercise regimen in a prospective clinical trial carried out at tertiary care institutions, Patients in the danazol/exercise group were instructed to exercise four times per week, for 40 min per session, at an intensity of 20 metabolic units. Side effect profiles, pelvic symptoms, aerobic fitness, strength and hormone levels were compared for all subjects. The number of side effects of danazol was analyzed by the method of generalized estimating equations, Results: The number of side effects reported during a 4-week period was 1.09-2.17 times greater for the danazol-only than for the danazol/exercise group. All patients had improvement of symptoms during treatment, The danazol/exercise group had significantly lower testosterone levels during treatment, The time to recurrence of endometriosis was not different between groups. Conclusions. Exercise during danazol therapy reduces the number of androgenic side effects. Relief of pain and time to recurrence are unaffected.