Lupinosis: response of sheep to different doses of phomopsin.
Lupinosis: response of sheep to different doses of phomopsin.
复制标题
羽扇豆病：绵羊对不同剂量拟茎点菌素的反应。
DOI：
10.1038/icb.1982.29
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
D. Campbell
中科院分区：
文献类型：
--
作者：
M. Jago;J. Peterson;A. Payne;D. Campbell
茎点霉毒素是由细茎点霉产生的一种真菌毒素，对绵羊具有很高的毒性。当在1 X 25至98 μ g/kg体重的剂量范围内单次皮下注射给药时，给予37 X 5 μ g/kg或更高剂量的所有绵羊均死亡。有些人，虽然不是全部，在较低剂量后死亡，最低致死剂量为10微克/公斤。在视黄蛋白给药后超过21天的肝脏反应时间过程之后，进行血浆生化分析，包括一些酶（谷氨酸脱氢酶、γ-谷氨酰转肽酶、天冬氨酸氨基转移酶和碱性磷酸酶）、总胆红素和溴磺酞清除率的测定。在2.5 μ g/kg及以上的所有剂量后，肝胆损伤明显，而1.25 μ g/kg接近"无作用"水平。
Phomopsin, the mycotoxin produced by Phomopsis leptostromiformis, was found to have a very high toxicity for sheep. When administered as a single, subcutaneous injection over the dose range 1 X 25 to 98 microgram/kg body weight, all sheep given 37 X 5 microgram/kg or more died. Some, though not all, died following lower doses, the minimum lethal dose being 10 microgram/kg. The time course of hepatic response over 21 days after phomopsin administration was followed by plasma biochemical analyses including those for some enzymes (glutamate dehydrogenase, gamma-glutamyl transpeptidase, aspartate aminotransferase and alkaline phosphatase), total bilirubin and the determination of bromosulphophthalein clearance rates. Hepatobiliary impairment was apparent after all dosages of 2.5 microgram/kg and above while 1.25 microgram/kg approximated the 'no effect' level.