Objectively assessed sleep and physical activity in depression subtypes and its mediating role in their association with cardiovascular risk factors.
Objectively assessed sleep and physical activity in depression subtypes and its mediating role in their association with cardiovascular risk factors.
复制标题
客观评估抑郁亚型的睡眠和体力活动及其在与心血管危险因素关联中的中介作用。
DOI：
10.1016/j.jpsychires.2023.05.042
复制
发表时间：
2023
影响因子：
4.8
通讯作者：
Preisig,Martin
中科院分区：
文献类型：
--
作者：
Glaus,Jennifer;Kang,SunJung;Guo,Wei;Lamers,Femke;Strippoli,Marie-PierreF;Leroux,Andrew;Dey,Debangan;Plessen,KerstinJ;Vaucher,Julien;Vollenweider,Peter;Zipunnikov,Vadim;Merikangas,KathleenR;Preisig,Martin
本研究的目的是探讨抑郁症及其亚型之间的关系（非典型、神经性、合并性、未指明）与活动记录仪衍生的睡眠、身体活动和昼夜节律测量;并测试睡眠的潜在中介作用，非典型MDD亚型与体重指数（BMI）之间已确立的相关性中的体力活动和昼夜节律代谢综合征（Metabolic Syndrome，MeS）样本包括2317名参与者从市区招募，谁进行了全面的躯体和精神评估。MDD及其亚型通过半结构化诊断访谈进行评估。睡眠，体力活动和昼夜节律进行了测量使用活动记录仪。MDD及其亚型与几个活动记录衍生的变量相关，包括较晚的睡眠中点，低体力活动，低日间稳定性和较大的睡眠持续时间和相对振幅的个体内变异性。睡眠中点和体力活动符合非典型MDD和BMI之间的关联的部分中介标准，体力活动也符合非典型MDD和MeS之间的关联的部分中介标准。我们的研究结果证实了抑郁症及其非典型亚型与睡眠和体力活动的相关性，这可能部分介导非典型抑郁症与BMI和MeS的相关性，尽管这些相关性中的大多数不能用睡眠和活动变量来解释。这强调了将非典型MDD、睡眠和久坐行为视为心血管风险因素的必要性。
The aims of this study were to investigate the associations of major depressive disorder (MDD) and its subtypes (atypical, melancholic, combined, unspecified) with actigraphy-derived measures of sleep, physical activity and circadian rhythms; and test the potentially mediating role of sleep, physical activity and circadian rhythms in the well-established associations of the atypical MDD subtype with Body Mass Index (BMI) and the metabolic syndrome (MeS). The sample consisted of 2317 participants recruited from an urban area, who underwent comprehensive somatic and psychiatric evaluations. MDD and its subtypes were assessed via semi-structured diagnostic interviews. Sleep, physical activity and circadian rhythms were measured using actigraphy. MDD and its subtypes were associated with several actigraphy-derived variables, including later sleep midpoint, low physical activity, low inter-daily stability and larger intra-individual variability of sleep duration and relative amplitude. Sleep midpoint and physical activity fulfilled criteria for partial mediation of the association between atypical MDD and BMI, and physical activity also for partial mediation of the association between atypical MDD and MeS. Our findings confirm associations of MDD and its atypical subtype with sleep and physical activity, which are likely to partially mediate the associations of atypical MDD with BMI and MeS, although most of these associations are not explained by sleep and activity variables. This highlights the need to consider atypical MDD, sleep and sedentary behavior as cardiovascular risk factors.