Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy
Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy
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DOI：
10.1039/c6nr00014b
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发表时间：
2016-01-01
期刊：
影响因子：
6.7
通讯作者：
Heger, M.
中科院分区：
文献类型：
--
作者：
Broekgaarden, M.;van Vught, R.;Heger, M.
治疗耐药癌症的光动力疗法将极大地受益于肿瘤光敏剂的靶向递送。在本研究中，开发并测试了一种将单域抗体位点特异性偶联到含有光敏剂酞菁锌的脂质体上的策略。
Photodynamic therapy for therapy-resistant cancers will greatly benefit from targeted delivery of tumor photosensitizing agents. In this study, a strategy for the site-specific conjugation of single domain antibodies onto liposomes containing the photosensitizer zinc phthalocyanine was developed and tested.