PI3 kinase signaling is required for retrieval and extinction of contextual memory
PI3 kinase signaling is required for retrieval and extinction of contextual memory
复制标题
DOI：
10.1038/nn1482
复制
发表时间：
2005-07-01
影响因子：
25
通讯作者：
Storm, DR
中科院分区：
文献类型：
--
作者：
Chen, X;Garelick, MG;Storm, DR
记忆提取是记忆形成的一个动态方面，可以与记忆加工的其他阶段分开研究。虽然包括ERK/MAP激酶在内的几个信号转导通路与记忆提取有关，但潜在的信号转导事件还不清楚。在这里，我们报告说，小鼠在情景训练后重新暴露在情景中，刺激了海马区磷脂酰肌醇3激酶(PI3K)的活性。抑制体内海马区的PI3K活性可以阻止情境记忆的恢复和消退。PI3K信号通路的抑制剂也阻断了与记忆恢复相关的ERK/MAP激酶活性的增加。这表明，海马区PI3K的激活对记忆提取是至关重要的，并且是在提取过程中激活ERK/MAP激酶所必需的。
Memory retrieval is a dynamic aspect of memory formation that can be studied separately from other stages of memory processing. Although several signal transduction pathways including ERK/MAP kinase have been implicated in memory retrieval, the underlying signaling events are poorly defined. Here we report that re-exposure of mice to context after contextual training stimulates the activity of phosphatidylinositol 3 kinase (PI3K) in the hippocampus. Inhibition of PI3K activity in the hippocampus in vivo blocked contextual memory retrieval and extinction. Inhibitors of PI3K signaling also blocked increases in ERK/MAP kinase activity associated with memory retrieval. This suggests that PI3K activation in the hippocampus is critical for memory retrieval and is required for activation of ERK/MAP kinase during retrieval.