Mapping human brain function with MEG and EEG: methods and validation
Mapping human brain function with MEG and EEG: methods and validation
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DOI：
10.1016/j.neuroimage.2004.07.014
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发表时间：
2004-01-01
期刊：
影响因子：
5.7
通讯作者：
Leahy, RM
中科院分区：
文献类型：
--
作者：
Darvas, F;Pantazis, D;Leahy, RM
本文综述了脑磁图（MEG）和脑电（EEG）源估计的研究现状。这些模式提供了潜在的功能性脑映射与时间分辨率在毫秒范围内。然而，有限数量的空间测量和不适定性的反问题提出了显着的限制，我们的能力，从这些数据产生准确的空间地图，而不施加重大限制的形式上的逆解。在这里，我们描述的方法来解决计算从假定的逆解映射到数据空间的正问题。然后，我们描述的逆问题的低维的解决方案，等效电流偶极子（ECD）的基础上，和高维的解决方案，其中图像的神经激活被约束到大脑皮层。我们还解决了这个问题的相对性能的逆程序的自由响应受试者工作特性（FROC）曲线的客观评估。最后，我们讨论的方法，通过使用的引导确定置信区域的偶极子拟合方法，和随机场（RF）和置换方法检测显着激活皮质约束成像研究的实验结果的统计学意义进行评估。(C)2004年爱思唯尔公司All rights reserved.
We survey the field of magnetoencephalography (MEG) and electro-encephalography (EEG) source estimation. These modalities offer the potential for functional brain mapping with temporal resolution in the millisecond range. However, the limited number of spatial measurements and the ill-posedness of the inverse problem present significant limits to our ability to produce accurate spatial maps from these data without imposing major restrictions on the form of the inverse solution. Here we describe approaches to solving the forward problem of computing the mapping from putative inverse solutions into the data space. We then describe the inverse problem in terms of low dimensional solutions, based on the equivalent current dipole (ECD), and high dimensional solutions, in which images of neural activation are constrained to the cerebral cortex. We also address the issue of objective assessment of the relative performance of inverse procedures by the free-response receiver operating characteristic (FROC) curve. We conclude with a discussion of methods for assessing statistical significance of experimental results through use of the bootstrap for determining confidence regions in dipole-fitting methods, and random field (RF) and permutation methods for detecting significant activation in cortically constrained imaging studies. (C) 2004 Elsevier Inc. All rights reserved.