A prospective study of drinking patterns in relation to risk of type 2 diabetes among men
A prospective study of drinking patterns in relation to risk of type 2 diabetes among men
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DOI：
10.2337/diabetes.50.10.2390
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发表时间：
2001-10-01
期刊：
影响因子：
7.7
通讯作者：
Rimm, EB
中科院分区：
文献类型：
--
作者：
Conigrave, KM;Hu, BF;Rimm, EB
使用一项为期12年的前瞻性研究的数据，我们确定了酒精消费模式作为2型糖尿病风险因素的重要性，该队列由46，892名美国男性卫生专业人员组成，他们完成了两年一次的邮寄问卷调查。总的来说，记录了1，571例新的2型糖尿病病例。与零饮酒相比，每天饮酒15-29 g与糖尿病风险降低36%相关（RR = 0.64; 95%CI 0.53-0.77）。如果将轻度饮酒者而不是戒酒者作为参照组，则适度饮酒与糖尿病之间的负相关性仍然存在（RR = 0.60，CI 0.50-0.73）。很少有重度饮酒者，但与那些饮酒量大于或等于50 g/天的人存在负相关（RR = 0.60，CI 0.43-0.84）。消费频率与糖尿病呈负相关。每周至少5天饮酒提供了最大的保护，即使每个饮酒日饮酒少于1杯（RR = 0.48，CI 0.27-0.86）。与不常饮酒者相比，在控制了平均每日饮酒量后，每周饮酒每增加一天，风险降低7%（95%CI 3-10%）。啤酒、白酒和白色葡萄酒之间存在相似和独立的反向关联。我们的研究结果表明，频繁饮酒可以最大限度地预防2型糖尿病，即使每天饮酒的水平很低。饮料的选择不会改变风险。
Using data from a 12-year prospective study, we determined the importance of the pattern of alcohol consumption as a risk factor for type 2 diabetes in a cohort of 46,892 U.S. male health professionals who completed biennial postal questionnaires. Overall, 1,571 new cases of type 2 diabetes were documented. Compared with zero alcohol consumption, consumption of 15-29 g/day of alcohol was associated with a 36% lower risk of diabetes (RR = 0.64; 95% CI 0.53-0.77). This inverse association between moderate consumption and diabetes remained if light drinkers rather than abstainers were used as the reference group (RR = 0.60, CI 0.50-0.73). There were few heavy drinkers, but the inverse association persisted to those drinking greater than or equal to 50 g/day of alcohol (RR = 0.60, Cl 0.43-0.84). Frequency of consumption was inversely associated with diabetes. Consumption of alcohol on at least 5 days/week provided the greatest protection, even when less than one drink per drinking day was consumed (RR = 0.48, Cl 0.27-0.86). Compared with infrequent drinkers, for each additional day per week that alcohol was consumed, risk was reduced by 7% (95% Cl 3-10%) after controlling for average daily consumption. There were similar and independent inverse associations for beer, liquor, and white wine. Our findings suggested that frequent alcohol consumption conveys the greatest protection against type 2 diabetes, even if the level of consumption per drinking day is low. Beverage choice did not alter risk.