Candida albicans clades.
Candida albicans clades.
复制标题
白色念珠菌进化枝。
DOI：
10.1016/s0928-8244(03)00242-6
复制
发表时间：
2003
影响因子：
--
通讯作者：
Pujol,Claude
中科院分区：
文献类型：
--
作者：
Soll,DavidR;Pujol,Claude
用复合探针CA3进行DNA指纹分析，发现白色念珠菌有5个分支：I组、II组、III组、SA组和E组。这些组具有地理特异性。SA组对南非相对特异(即高度浓缩)，E组对欧洲相对特异，而II组在美国西南部和南美洲不存在。在相同的地理环境中，根深蒂固的支系并排存在，亚支系结构明显缺失，这表明支系之间的重组很少，但支系内的重组速率较高。大多数I组分离株对5-氟胞嘧啶的独占性耐药加强了上述关于重组的结论，并表明分支表型不同。对这些发现在发病机制方面的影响进行了讨论。特别是，这些发现推翻了一种菌株代表所有OFC菌株的想法。白念珠菌，支持需要在世界范围内分析种群结构和支系特有的表型特征，并表明，今后必须分析来自所有五个支系的代表的致病特征。
DNA fingerprinting with the complex probe Ca3 has revealed the following fiveCandida albicansclades: group I, group II, group III, group SA and group E. These groups exhibit geographical specificity. Group SA is relatively specific (i.e., highly enriched) to South Africa, group E is relatively specific to Europe, and group II is absent in the Southwest USA and South America. The maintenance of deep-rooted clades side by side in the same geographical locale and the apparent absence of subclade structure suggest little recombination between clades, but higher rates of recombination within clades. Exclusive 5-fluorocytosine resistance in the majority of group I isolates reinforces the above conclusions on recombination, and demonstrates that clades differ phenotypically. The ramifications of these findings with regard to pathogenesis are discussed. In particular, these findings lay to rest the idea that one strain represents all strains ofC. albicans, support the need for a worldwide analysis of population structure and clade-specific phenotypic characteristics, and demonstrate that in the future, pathogenic characteristics must be analyzed in representatives from all five clades.