Cervical Cancer Screening and Analysis of Potential Risk Factors in 43,567 Women in Zhongshan, China
Cervical Cancer Screening and Analysis of Potential Risk Factors in 43,567 Women in Zhongshan, China
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中国中山市43,567名女性宫颈癌筛查及潜在危险因素分析
DOI：
10.7314/apjcp.2014.15.2.671
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发表时间：
2014-01-01
影响因子：
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通讯作者：
Huang, Xiang
中科院分区：
文献类型：
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作者：
Wang, Ying;Yu, Yan-Hong;Huang, Xiang
目的：本研究的目的是建立一个广泛应用于宫颈癌筛查的程序模型。方法：在广东省中山市进行宫颈癌筛查，中国通过多个机构和医院的协调网络进行筛查。共有43,567名年龄在35岁至59岁之间的女性在常规妇科检查中使用液基薄层细胞学检测(TCT)进行了筛查。检测呈阳性的患者被召回接受进一步治疗。结果：TCT阳性率为3.17%，63.4%的患者复诊。在被召回的女性中，30.5%的病理结果呈阳性。年龄在50岁以下、居住在城市、低收入、有宫颈病史、在20岁之前开始性行为或在月经期发生性行为的女性，TCT检测呈阳性的风险较高。回忆率在50岁以上、居住在城市、受教育程度较低以及很早就开始发生性行为的女性中较低。在城市居住的35岁及以下的女性、24岁后首次发生性行为的女性以及在月经期间发生性行为的女性中，召回率更高。在50岁及以下的城市妇女和人乳头瘤病毒检测阳性的妇女中，阳性病理发生率较高。结论：成功建立了大规模宫颈癌筛查的有效模式。这些结果表明，需要改进对年轻和受教育程度较低的妇女进行宫颈癌筛查的基础教育。为了有效地控制宫颈癌，改善随访的外展也是必要的。
Objective: The objective of this study was to establish a program model for use in wide-spread cervical cancer screening. Methods: Cervical cancer screening was conducted in Zhongshan city in Guangdong province, China through a coordinated network of multiple institutes and hospitals. A total of 43,567 women, 35 to 59 years of age, were screened during regular gynecological examinations using the liquid-based ThinPrep cytology test (TCT). Patients who tested positive were recalled for further treatment. Results: The TCT-positive rate was 3.17%, and 63.4% of these patients returned for follow-up. Pathology results were positive for 30.5% of the recalled women. Women who were younger than 50 years of age, urban dwelling, low-income, had a history of cervical disease, began having sex before 20 years of age, or had sex during menstruation, were at elevated risk for a positive TCT test. The recall rate was lower in women older than 50 years of age, urban dwelling, poorly educated, and who began having sex early. A higher recall rate was found in women 35 years of age and younger, urban dwelling, women who first had sex after 24 years of age, and women who had sex during menstruation. The positive pathology rate was higher in urban women 50 years of age and younger and women who tested positive for human papillomavirus. Conclusion: An effective model for large-scale cervical cancer screening was successfully established. These results suggest that improvements are needed in basic education regarding cervical cancer screening for young and poorly educated women. Improved outreach for follow-up is also necessary to effectively control cervical cancer.