Thin Film Nitinol Covered Stents: Design and Animal Testing
Thin Film Nitinol Covered Stents: Design and Animal Testing
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薄膜镍钛诺覆盖支架：设计和动物测试
DOI：
10.1097/mat.0b013e31816b43b0
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发表时间：
2008
期刊：
影响因子：
4.2
通讯作者：
G. Carman
中科院分区：
文献类型：
--
作者：
D. Levi;Ryan J Williams;Jasen Liu;Saar Danon;L. Stepan;M. Panduranga;M. Fishbein;G. Carman
许多专业的介入医生需要改进的低切迹覆膜支架。镍钛诺薄膜（<5-10微米）可用于改善当前的覆膜支架技术。一个“热靶”溅射沉积技术被用来创建镍钛合金薄膜的这项研究。覆膜支架由市售球囊扩张和自膨式支架制成。支架在实验室流动回路中展开，并在4头猪中展开。未覆膜支架部分作为对照。在植入后2-6周进行尸检。在短期试验中，在动脉循环中展开的薄膜镍钛合金覆膜支架显示无内膜增生，并且在死后很容易从动脉壁中取出。扫描电子显微镜显示薄膜上有一薄层内皮细胞，3周时覆盖整个薄膜。相比之下，在静脉循环中展开的支架的管腔侧发生了显著的新生内膜增生。极低剖面覆膜支架可以使用镍钛诺薄膜制造。尽管需要长期研究，但薄膜镍钛合金可能有助于开发低切迹、无血栓形成的覆膜支架。
Interventionalists in many specialties have the need for improved, low profile covered stents. Thin films of nitinol (<5–10 microns) could be used to improve current covered stent technology. A “hot target” sputter deposition technique was used to create thin films of nitinol for this study. Covered stents were created from commercially available balloon-inflatable and self-expanding stents. Stents were deployed in a laboratory flow loop and in four swine. Uncovered stent portions served as controls. Postmortem examinations were performed 2–6 weeks after implantation. In short-term testing, thin film nitinol covered stents deployed in the arterial circulation showed no intimal proliferation and were easily removed from the arterial wall postmortem. Scanning electron microscopy showed a thin layer of endothelial cells on the thin film, which covered the entire film by 3 weeks. By contrast, significant neointimal hyperplasia occurred on the luminal side of stents deployed in the venous circulation. Extremely low-profile covered stents can be manufactured using thin films of nitinol. Although long-term studies are needed, thin film nitinol may allow for the development of low-profile, nonthrombogenic covered stents.